R35 HL145203/HL/NHLBI NIH HHS/United States[Grants and Funding] - Search Results

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Subject: R35 HL145203/HL/NHLBI NIH HHS/United States[Grant - PubMed

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Results by year

Year	Number of Results
2021	2
2022	2
2023	6
2024	3

11 results

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Improved specificity and efficacy of base-editing therapies with hybrid guide RNAs.

Whittaker MN, Brooks DL, Quigley A, Jindal I, Qu P, Wang JZ, Ahrens-Nicklas RC, Musunuru K, Alameh MG, Peranteau WH, Wang X. Whittaker MN, et al. bioRxiv [Preprint]. 2024 Apr 23:2024.04.22.590531. doi: 10.1101/2024.04.22.590531. bioRxiv. 2024. PMID: 38712058 Free PMC article. Preprint.

A base editing strategy using mRNA-LNPs for in vivo correction of the most frequent phenylketonuria variant.

Brooks DL, Whittaker MN, Said H, Dwivedi G, Qu P, Musunuru K, Ahrens-Nicklas RC, Alameh MG, Wang X. Brooks DL, et al. HGG Adv. 2024 Jan 11;5(1):100253. doi: 10.1016/j.xhgg.2023.100253. Epub 2023 Nov 2. HGG Adv. 2024. PMID: 37922902 Free PMC article.

Efficient in vivo prime editing corrects the most frequent phenylketonuria variant, associated with high unmet medical need.

Brooks DL, Whittaker MN, Qu P, Musunuru K, Ahrens-Nicklas RC, Wang X. Brooks DL, et al. Am J Hum Genet. 2023 Dec 7;110(12):2003-2014. doi: 10.1016/j.ajhg.2023.10.005. Epub 2023 Nov 3. Am J Hum Genet. 2023. PMID: 37924808 Free PMC article.

Epigenome Editing Durability Varies Widely Across Cardiovascular Disease Target Genes.

Whittaker MN, Testa LC, Quigley A, Jindal I, Cortez-Alvarado SV, Qu P, Yang Y, Alameh MG, Musunuru K, Wang X. Whittaker MN, et al. Arterioscler Thromb Vasc Biol. 2023 Oct;43(10):2075-2077. doi: 10.1161/ATVBAHA.123.319748. Epub 2023 Aug 17. Arterioscler Thromb Vasc Biol. 2023. PMID: 37589141 No abstract available.

Rapid and definitive treatment of phenylketonuria in variant-humanized mice with corrective editing.

Brooks DL, Carrasco MJ, Qu P, Peranteau WH, Ahrens-Nicklas RC, Musunuru K, Alameh MG, Wang X. Brooks DL, et al. Nat Commun. 2023 Jun 10;14(1):3451. doi: 10.1038/s41467-023-39246-2. Nat Commun. 2023. PMID: 37301931 Free PMC article.

Epigenome Editing Durability Varies Widely Across Cardiovascular Disease Target Genes.

Whittaker MN, Testa LC, Quigley A, Jindal I, Cortez-Alvarado SV, Qu P, Yang Y, Alameh MG, Musunuru K, Wang X. Whittaker MN, et al. bioRxiv [Preprint]. 2023 May 17:2023.05.17.541156. doi: 10.1101/2023.05.17.541156. bioRxiv. 2023. PMID: 37292627 Free PMC article. Updated. Preprint.

Efficient prime editing in mouse brain, liver and heart with dual AAVs.

Davis JR, Banskota S, Levy JM, Newby GA, Wang X, Anzalone AV, Nelson AT, Chen PJ, Hennes AD, An M, Roh H, Randolph PB, Musunuru K, Liu DR. Davis JR, et al. Nat Biotechnol. 2024 Feb;42(2):253-264. doi: 10.1038/s41587-023-01758-z. Epub 2023 May 4. Nat Biotechnol. 2024. PMID: 37142705 Free PMC article.

Efficient in vivo base editing via single adeno-associated viruses with size-optimized genomes encoding compact adenine base editors.

Davis JR, Wang X, Witte IP, Huang TP, Levy JM, Raguram A, Banskota S, Seidah NG, Musunuru K, Liu DR. Davis JR, et al. Nat Biomed Eng. 2022 Nov;6(11):1272-1283. doi: 10.1038/s41551-022-00911-4. Epub 2022 Jul 28. Nat Biomed Eng. 2022. PMID: 35902773 Free PMC article.

Engineered virus-like particles for efficient in vivo delivery of therapeutic proteins.

Banskota S, Raguram A, Suh S, Du SW, Davis JR, Choi EH, Wang X, Nielsen SC, Newby GA, Randolph PB, Osborn MJ, Musunuru K, Palczewski K, Liu DR. Banskota S, et al. Cell. 2022 Jan 20;185(2):250-265.e16. doi: 10.1016/j.cell.2021.12.021. Epub 2022 Jan 11. Cell. 2022. PMID: 35021064 Free PMC article.

Adenine base editing to treat progeria syndrome and extend the lifespan.

Musunuru K. Musunuru K. J Cardiovasc Aging. 2021;1:8. doi: 10.20517/jca.2021.10. Epub 2021 Jun 17. J Cardiovasc Aging. 2021. PMID: 34308436 Free PMC article.

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