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Hyperactivated PI3Kδ promotes self and commensal reactivity at the expense of optimal humoral immunity.
Preite S, Cannons JL, Radtke AJ, Vujkovic-Cvijin I, Gomez-Rodriguez J, Volpi S, Huang B, Cheng J, Collins N, Reilley J, Handon R, Dobbs K, Huq L, Raman I, Zhu C, Li QZ, Li MO, Pittaluga S, Uzel G, Notarangelo LD, Belkaid Y, Germain RN, Schwartzberg PL. Preite S, et al. Among authors: radtke aj. Nat Immunol. 2018 Sep;19(9):986-1000. doi: 10.1038/s41590-018-0182-3. Epub 2018 Aug 20. Nat Immunol. 2018. PMID: 30127432 Free PMC article.
Commensal-driven immune zonation of the liver promotes host defence.
Gola A, Dorrington MG, Speranza E, Sala C, Shih RM, Radtke AJ, Wong HS, Baptista AP, Hernandez JM, Castellani G, Fraser IDC, Germain RN. Gola A, et al. Among authors: radtke aj. Nature. 2021 Jan;589(7840):131-136. doi: 10.1038/s41586-020-2977-2. Epub 2020 Nov 25. Nature. 2021. PMID: 33239787 Free PMC article.
IBEX: A versatile multiplex optical imaging approach for deep phenotyping and spatial analysis of cells in complex tissues.
Radtke AJ, Kandov E, Lowekamp B, Speranza E, Chu CJ, Gola A, Thakur N, Shih R, Yao L, Yaniv ZR, Beuschel RT, Kabat J, Croteau J, Davis J, Hernandez JM, Germain RN. Radtke AJ, et al. Proc Natl Acad Sci U S A. 2020 Dec 29;117(52):33455-33465. doi: 10.1073/pnas.2018488117. Epub 2020 Dec 21. Proc Natl Acad Sci U S A. 2020. PMID: 33376221 Free PMC article.
38 results