Rajagopalan S - Search Results

1

Electron microscopy studies on the quaternary structure of p53 reveal different binding modes for p53 tetramers in complex with DNA.

Melero R, Rajagopalan S, Lázaro M, Joerger AC, Brandt T, Veprintsev DB, Lasso G, Gil D, Scheres SH, Carazo JM, Fersht AR, Valle M. Melero R, et al. Among authors: rajagopalan s. Proc Natl Acad Sci U S A. 2011 Jan 11;108(2):557-62. doi: 10.1073/pnas.1015520107. Epub 2010 Dec 22. Proc Natl Acad Sci U S A. 2011. PMID: 21178074 Free PMC article.

2

Structural evolution of p53, p63, and p73: implication for heterotetramer formation.

Joerger AC, Rajagopalan S, Natan E, Veprintsev DB, Robinson CV, Fersht AR. Joerger AC, et al. Among authors: rajagopalan s. Proc Natl Acad Sci U S A. 2009 Oct 20;106(42):17705-10. doi: 10.1073/pnas.0905867106. Epub 2009 Oct 7. Proc Natl Acad Sci U S A. 2009. PMID: 19815500 Free PMC article.

3

14-3-3 activation of DNA binding of p53 by enhancing its association into tetramers.

Rajagopalan S, Jaulent AM, Wells M, Veprintsev DB, Fersht AR. Rajagopalan S, et al. Nucleic Acids Res. 2008 Oct;36(18):5983-91. doi: 10.1093/nar/gkn598. Epub 2008 Sep 23. Nucleic Acids Res. 2008. PMID: 18812399 Free PMC article.

4

Multiple conformations of full-length p53 detected with single-molecule fluorescence resonance energy transfer.

Huang F, Rajagopalan S, Settanni G, Marsh RJ, Armoogum DA, Nicolaou N, Bain AJ, Lerner E, Haas E, Ying L, Fersht AR. Huang F, et al. Among authors: rajagopalan s. Proc Natl Acad Sci U S A. 2009 Dec 8;106(49):20758-63. doi: 10.1073/pnas.0909644106. Epub 2009 Nov 20. Proc Natl Acad Sci U S A. 2009. PMID: 19933326 Free PMC article.

5

Mapping the physical and functional interactions between the tumor suppressors p53 and BRCA2.

Rajagopalan S, Andreeva A, Rutherford TJ, Fersht AR. Rajagopalan S, et al. Proc Natl Acad Sci U S A. 2010 May 11;107(19):8587-92. doi: 10.1073/pnas.1003689107. Epub 2010 Apr 26. Proc Natl Acad Sci U S A. 2010. PMID: 20421506 Free PMC article.

6

Single-Molecule characterization of oligomerization kinetics and equilibria of the tumor suppressor p53.

Rajagopalan S, Huang F, Fersht AR. Rajagopalan S, et al. Nucleic Acids Res. 2011 Mar;39(6):2294-303. doi: 10.1093/nar/gkq800. Epub 2010 Nov 18. Nucleic Acids Res. 2011. PMID: 21097469 Free PMC article.

7

Mechanistic differences in the transcriptional activation of p53 by 14-3-3 isoforms.

Rajagopalan S, Sade RS, Townsley FM, Fersht AR. Rajagopalan S, et al. Nucleic Acids Res. 2010 Jan;38(3):893-906. doi: 10.1093/nar/gkp1041. Epub 2009 Nov 20. Nucleic Acids Res. 2010. PMID: 19933256 Free PMC article.

8

Interaction between the transactivation domain of p53 and PC4 exemplifies acidic activation domains as single-stranded DNA mimics.

Rajagopalan S, Andreeva A, Teufel DP, Freund SM, Fersht AR. Rajagopalan S, et al. J Biol Chem. 2009 Aug 7;284(32):21728-37. doi: 10.1074/jbc.M109.006429. Epub 2009 Jun 12. J Biol Chem. 2009. PMID: 19525231 Free PMC article.

9

Physical and functional interactions between human mitochondrial single-stranded DNA-binding protein and tumour suppressor p53.

Wong TS, Rajagopalan S, Townsley FM, Freund SM, Petrovich M, Loakes D, Fersht AR. Wong TS, et al. Among authors: rajagopalan s. Nucleic Acids Res. 2009 Feb;37(2):568-81. doi: 10.1093/nar/gkn974. Epub 2008 Dec 9. Nucleic Acids Res. 2009. PMID: 19066201 Free PMC article.

10

Biophysical characterizations of human mitochondrial transcription factor A and its binding to tumor suppressor p53.

Wong TS, Rajagopalan S, Freund SM, Rutherford TJ, Andreeva A, Townsley FM, Petrovich M, Fersht AR. Wong TS, et al. Among authors: rajagopalan s. Nucleic Acids Res. 2009 Nov;37(20):6765-83. doi: 10.1093/nar/gkp750. Epub 2009 Sep 15. Nucleic Acids Res. 2009. PMID: 19755502 Free PMC article.

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