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GAD1 (2q31.1), which encodes glutamic acid decarboxylase (GAD67), is associated with childhood-onset schizophrenia and cortical gray matter volume loss.
Addington AM, Gornick M, Duckworth J, Sporn A, Gogtay N, Bobb A, Greenstein D, Lenane M, Gochman P, Baker N, Balkissoon R, Vakkalanka RK, Weinberger DR, Rapoport JL, Straub RE. Addington AM, et al. Among authors: rapoport jl. Mol Psychiatry. 2005 Jun;10(6):581-8. doi: 10.1038/sj.mp.4001599. Mol Psychiatry. 2005. PMID: 15505639 Clinical Trial.
Catechol-o-methyl transferase (COMT) val158met polymorphism and adolescent cortical development in patients with childhood-onset schizophrenia, their non-psychotic siblings, and healthy controls.
Raznahan A, Greenstein D, Lee Y, Long R, Clasen L, Gochman P, Addington A, Giedd JN, Rapoport JL, Gogtay N. Raznahan A, et al. Among authors: rapoport jl. Neuroimage. 2011 Aug 15;57(4):1517-23. doi: 10.1016/j.neuroimage.2011.05.032. Epub 2011 May 15. Neuroimage. 2011. PMID: 21620981 Free PMC article.
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