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Benzofuran sulfonates and small self-lipid antigens activate type II NKT cells via CD1d.
Almeida CF, Smith DGM, Cheng TY, Harpur CM, Batleska E, Nguyen-Robertson CV, Nguyen T, Thelemann T, Reddiex SJJ, Li S, Eckle SBG, Van Rhijn I, Rossjohn J, Uldrich AP, Moody DB, Williams SJ, Pellicci DG, Godfrey DI. Almeida CF, et al. Among authors: reddiex sjj. Proc Natl Acad Sci U S A. 2021 Aug 24;118(34):e2104420118. doi: 10.1073/pnas.2104420118. Proc Natl Acad Sci U S A. 2021. PMID: 34417291 Free PMC article.
Endoplasmic reticulum chaperones stabilize ligand-receptive MR1 molecules for efficient presentation of metabolite antigens.
McWilliam HEG, Mak JYW, Awad W, Zorkau M, Cruz-Gomez S, Lim HJ, Yan Y, Wormald S, Dagley LF, Eckle SBG, Corbett AJ, Liu H, Li S, Reddiex SJJ, Mintern JD, Liu L, McCluskey J, Rossjohn J, Fairlie DP, Villadangos JA. McWilliam HEG, et al. Among authors: reddiex sjj. Proc Natl Acad Sci U S A. 2020 Oct 6;117(40):24974-24985. doi: 10.1073/pnas.2011260117. Epub 2020 Sep 21. Proc Natl Acad Sci U S A. 2020. PMID: 32958637 Free PMC article.
A single-domain bispecific antibody targeting CD1d and the NKT T-cell receptor induces a potent antitumor response.
Lameris R, Shahine A, Pellicci DG, Uldrich AP, Gras S, Le Nours J, Groen RWJ, Vree J, Reddiex SJJ, Quiñones-Parra SM, Richardson SK, Howell AR, Zweegman S, Godfrey DI, de Gruijl TD, Rossjohn J, van der Vliet HJ. Lameris R, et al. Among authors: reddiex sjj. Nat Cancer. 2020 Nov;1(11):1054-1065. doi: 10.1038/s43018-020-00111-6. Epub 2020 Sep 14. Nat Cancer. 2020. PMID: 35122066
Total Synthesis of Mycobacterium tuberculosis Dideoxymycobactin-838 and Stereoisomers: Diverse CD1a-Restricted T Cells Display a Common Hierarchy of Lipopeptide Recognition.
Cheng JM, Liu L, Pellicci DG, Reddiex SJ, Cotton RN, Cheng TY, Young DC, Van Rhijn I, Moody DB, Rossjohn J, Fairlie DP, Godfrey DI, Williams SJ. Cheng JM, et al. Chemistry. 2017 Jan 31;23(7):1694-1701. doi: 10.1002/chem.201605287. Epub 2017 Jan 18. Chemistry. 2017. PMID: 27925318 Free PMC article.