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A non-ATP-competitive inhibitor of BCR-ABL overrides imatinib resistance.
Gumireddy K, Baker SJ, Cosenza SC, John P, Kang AD, Robell KA, Reddy MV, Reddy EP. Gumireddy K, et al. Among authors: reddy mv, reddy ep. Proc Natl Acad Sci U S A. 2005 Feb 8;102(6):1992-7. doi: 10.1073/pnas.0408283102. Epub 2005 Jan 27. Proc Natl Acad Sci U S A. 2005. PMID: 15677719 Free PMC article.
A Contaminant Impurity, Not Rigosertib, Is a Tubulin Binding Agent.
Baker SJ, Cosenza SC, Athuluri-Divakar S, Reddy MVR, Vasquez-Del Carpio R, Jain R, Aggarwal AK, Reddy EP. Baker SJ, et al. Mol Cell. 2020 Jul 2;79(1):180-190.e4. doi: 10.1016/j.molcel.2020.05.024. Mol Cell. 2020. PMID: 32619468 Free PMC article.
(Z)-1-aryl-3-arylamino-2-propen-1-ones, highly active stimulators of tubulin polymerization: synthesis, structure-activity relationship (SAR), tubulin polymerization, and cell growth inhibition studies.
Reddy MV, Akula B, Cosenza SC, Lee CM, Mallireddigari MR, Pallela VR, Subbaiah DR, Udofa A, Reddy EP. Reddy MV, et al. Among authors: reddy ep. J Med Chem. 2012 Jun 14;55(11):5174-87. doi: 10.1021/jm300176j. Epub 2012 May 25. J Med Chem. 2012. PMID: 22587519 Free PMC article.
Discovery of 8-cyclopentyl-2-[4-(4-methyl-piperazin-1-yl)-phenylamino]-7-oxo-7,8-dihydro-pyrido[2,3-d]pyrimidine-6-carbonitrile (7x) as a potent inhibitor of cyclin-dependent kinase 4 (CDK4) and AMPK-related kinase 5 (ARK5).
Reddy MV, Akula B, Cosenza SC, Athuluridivakar S, Mallireddigari MR, Pallela VR, Billa VK, Subbaiah DR, Bharathi EV, Vasquez-Del Carpio R, Padgaonkar A, Baker SJ, Reddy EP. Reddy MV, et al. Among authors: reddy ep. J Med Chem. 2014 Feb 13;57(3):578-99. doi: 10.1021/jm401073p. Epub 2014 Jan 24. J Med Chem. 2014. PMID: 24417566 Free PMC article.
417 results