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Multi-Modal Characterization of Monocytes in Idiopathic Pulmonary Fibrosis Reveals a Primed Type I Interferon Immune Phenotype.
Fraser E, Denney L, Antanaviciute A, Blirando K, Vuppusetty C, Zheng Y, Repapi E, Iotchkova V, Taylor S, Ashley N, St Noble V, Benamore R, Hoyles R, Clelland C, Rastrick JMD, Hardman CS, Alham NK, Rigby RE, Simmons A, Rehwinkel J, Ho LP. Fraser E, et al. Among authors: rehwinkel j. Front Immunol. 2021 Mar 5;12:623430. doi: 10.3389/fimmu.2021.623430. eCollection 2021. Front Immunol. 2021. PMID: 33746960 Free PMC article.
RNA degradation in antiviral immunity and autoimmunity.
Rigby RE, Rehwinkel J. Rigby RE, et al. Among authors: rehwinkel j. Trends Immunol. 2015 Mar;36(3):179-88. doi: 10.1016/j.it.2015.02.001. Epub 2015 Feb 20. Trends Immunol. 2015. PMID: 25709093 Free PMC article. Review.
Infection with a Brazilian isolate of Zika virus generates RIG-I stimulatory RNA and the viral NS5 protein blocks type I IFN induction and signaling.
Hertzog J, Dias Junior AG, Rigby RE, Donald CL, Mayer A, Sezgin E, Song C, Jin B, Hublitz P, Eggeling C, Kohl A, Rehwinkel J. Hertzog J, et al. Among authors: rehwinkel j. Eur J Immunol. 2018 Jul;48(7):1120-1136. doi: 10.1002/eji.201847483. Epub 2018 Apr 6. Eur J Immunol. 2018. PMID: 29572905 Free PMC article.
Nitro-fatty acids are formed in response to virus infection and are potent inhibitors of STING palmitoylation and signaling.
Hansen AL, Buchan GJ, Rühl M, Mukai K, Salvatore SR, Ogawa E, Andersen SD, Iversen MB, Thielke AL, Gunderstofte C, Motwani M, Møller CT, Jakobsen AS, Fitzgerald KA, Roos J, Lin R, Maier TJ, Goldbach-Mansky R, Miner CA, Qian W, Miner JJ, Rigby RE, Rehwinkel J, Jakobsen MR, Arai H, Taguchi T, Schopfer FJ, Olagnier D, Holm CK. Hansen AL, et al. Among authors: rehwinkel j. Proc Natl Acad Sci U S A. 2018 Aug 14;115(33):E7768-E7775. doi: 10.1073/pnas.1806239115. Epub 2018 Jul 30. Proc Natl Acad Sci U S A. 2018. PMID: 30061387 Free PMC article.
Deoxyguanosine is a TLR7 agonist.
Davenne T, Bridgeman A, Rigby RE, Rehwinkel J. Davenne T, et al. Among authors: rehwinkel j. Eur J Immunol. 2020 Jan;50(1):56-62. doi: 10.1002/eji.201948151. Epub 2019 Nov 14. Eur J Immunol. 2020. PMID: 31608988 Free PMC article.
Varicella-Zoster virus ORF9 is an antagonist of the DNA sensor cGAS.
Hertzog J, Zhou W, Fowler G, Rigby RE, Bridgeman A, Blest HT, Cursi C, Chauveau L, Davenne T, Warner BE, Kinchington PR, Kranzusch PJ, Rehwinkel J. Hertzog J, et al. Among authors: rehwinkel j. EMBO J. 2022 Jul 18;41(14):e109217. doi: 10.15252/embj.2021109217. Epub 2022 Jun 7. EMBO J. 2022. PMID: 35670106 Free PMC article.
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