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Molecular mechanism of anesthetic-induced depression of myocardial contraction.
Meng T, Bu W, Ren X, Chen X, Yu J, Eckenhoff RG, Gao WD. Meng T, et al. Among authors: ren x. FASEB J. 2016 Aug;30(8):2915-25. doi: 10.1096/fj.201600290RR. Epub 2016 May 11. FASEB J. 2016. PMID: 27170289 Free PMC article.
Thus, propofol and isoflurane decrease force development by directly depressing myofilament Ca(2+) responsiveness and have binding sites in key regions for contraction in both actin and myosin.-Meng, T., Bu, W., Ren, X., Chen, X., Yu, J., Eckenhoff, R. G., Ga …
Thus, propofol and isoflurane decrease force development by directly depressing myofilament Ca(2+) responsiveness and have binding sites in …
Fropofol decreases force development in cardiac muscle.
Ren X, Schmidt W, Huang Y, Lu H, Liu W, Bu W, Eckenhoff R, Cammarato A, Gao WD. Ren X, et al. FASEB J. 2018 Aug;32(8):4203-4213. doi: 10.1096/fj.201701442R. Epub 2018 Mar 9. FASEB J. 2018. PMID: 29522375 Free PMC article.
From a clinical standpoint, these findings are particularly significant, given that fropofol is a nonanesthetic small molecule that decreases myocardial contractility specifically and thus may be useful in the treatment of hypercontractile cardiac disorders.-Ren, X. …
From a clinical standpoint, these findings are particularly significant, given that fropofol is a nonanesthetic small molecule that decrease …
Right ventricular diastolic dysfunction and failure: a review.
Jung YH, Ren X, Suffredini G, Dodd-O JM, Gao WD. Jung YH, et al. Among authors: ren x. Heart Fail Rev. 2022 Jul;27(4):1077-1090. doi: 10.1007/s10741-021-10123-8. Epub 2021 May 19. Heart Fail Rev. 2022. PMID: 34013436 Review.
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