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Bexarotene induces dyslipidemia by increased very low-density lipoprotein production and cholesteryl ester transfer protein-mediated reduction of high-density lipoprotein.
de Vries-van der Weij J, de Haan W, Hu L, Kuif M, Oei HL, van der Hoorn JW, Havekes LM, Princen HM, Romijn JA, Smit JW, Rensen PC. de Vries-van der Weij J, et al. Endocrinology. 2009 May;150(5):2368-75. doi: 10.1210/en.2008-1540. Epub 2009 Jan 15. Endocrinology. 2009. PMID: 19147676 Clinical Trial.
PXR agonism decreases plasma HDL levels in ApoE3-Leiden.CETP mice.
de Haan W, de Vries-van der Weij J, Mol IM, Hoekstra M, Romijn JA, Jukema JW, Havekes LM, Princen HM, Rensen PC. de Haan W, et al. Biochim Biophys Acta. 2009 Mar;1791(3):191-7. doi: 10.1016/j.bbalip.2008.12.008. Epub 2008 Dec 25. Biochim Biophys Acta. 2009. PMID: 19150509
BMP7 activates brown adipose tissue and reduces diet-induced obesity only at subthermoneutrality.
Boon MR, van den Berg SA, Wang Y, van den Bossche J, Karkampouna S, Bauwens M, De Saint-Hubert M, van der Horst G, Vukicevic S, de Winther MP, Havekes LM, Jukema JW, Tamsma JT, van der Pluijm G, van Dijk KW, Rensen PC. Boon MR, et al. PLoS One. 2013 Sep 16;8(9):e74083. doi: 10.1371/journal.pone.0074083. eCollection 2013. PLoS One. 2013. PMID: 24066098 Free PMC article.
392 results