Rewcastle GW - Search Results

1

IκB kinase β (IKKβ) does not mediate feedback inhibition of the insulin signalling cascade.

Lancaster GI, Skiba B, Yang C, Nicholls HT, Langley KG, Chan MH, Bruce CR, Rewcastle GW, Shepherd PR, Karin M, Febbraio MA. Lancaster GI, et al. Among authors: rewcastle gw. Biochem J. 2012 Mar 15;442(3):723-32. doi: 10.1042/BJ20112037. Biochem J. 2012. PMID: 22364283

2

Evidence for functional redundancy of class IA PI3K isoforms in insulin signalling.

Chaussade C, Rewcastle GW, Kendall JD, Denny WA, Cho K, Grønning LM, Chong ML, Anagnostou SH, Jackson SP, Daniele N, Shepherd PR. Chaussade C, et al. Among authors: rewcastle gw. Biochem J. 2007 Jun 15;404(3):449-58. doi: 10.1042/BJ20070003. Biochem J. 2007. PMID: 17362206 Free PMC article.

3

A drug targeting only p110α can block phosphoinositide 3-kinase signalling and tumour growth in certain cell types.

Jamieson S, Flanagan JU, Kolekar S, Buchanan C, Kendall JD, Lee WJ, Rewcastle GW, Denny WA, Singh R, Dickson J, Baguley BC, Shepherd PR. Jamieson S, et al. Among authors: rewcastle gw. Biochem J. 2011 Aug 15;438(1):53-62. doi: 10.1042/BJ20110502. Biochem J. 2011. PMID: 21668414 Free PMC article.

4

Effects of acutely inhibiting PI3K isoforms and mTOR on regulation of glucose metabolism in vivo.

Smith GC, Ong WK, Rewcastle GW, Kendall JD, Han W, Shepherd PR. Smith GC, et al. Among authors: rewcastle gw. Biochem J. 2012 Feb 15;442(1):161-9. doi: 10.1042/BJ20111913. Biochem J. 2012. PMID: 22142257 Free PMC article.

5

Functional differences between two classes of oncogenic mutation in the PIK3CA gene.

Chaussade C, Cho K, Mawson C, Rewcastle GW, Shepherd PR. Chaussade C, et al. Among authors: rewcastle gw. Biochem Biophys Res Commun. 2009 Apr 17;381(4):577-81. doi: 10.1016/j.bbrc.2009.02.081. Epub 2009 Feb 20. Biochem Biophys Res Commun. 2009. PMID: 19233141

6

Combining properties of different classes of PI3Kα inhibitors to understand the molecular features that confer selectivity.

Gong GQ, Kendall JD, Dickson JMJ, Rewcastle GW, Buchanan CM, Denny WA, Shepherd PR, Flanagan JU. Gong GQ, et al. Among authors: rewcastle gw. Biochem J. 2017 Jun 26;474(13):2261-2276. doi: 10.1042/BCJ20161098. Biochem J. 2017. PMID: 28526744

7

DMXAA (Vadimezan, ASA404) is a multi-kinase inhibitor targeting VEGFR2 in particular.

Buchanan CM, Shih JH, Astin JW, Rewcastle GW, Flanagan JU, Crosier PS, Shepherd PR. Buchanan CM, et al. Among authors: rewcastle gw. Clin Sci (Lond). 2012 May 1;122(10):449-57. doi: 10.1042/CS20110412. Clin Sci (Lond). 2012. PMID: 22142330

8

Extended treatment with selective phosphatidylinositol 3-kinase and mTOR inhibitors has effects on metabolism, growth, behaviour and bone strength.

Smith GC, Ong WK, Costa JL, Watson M, Cornish J, Grey A, Gamble GD, Dickinson M, Leung S, Rewcastle GW, Han W, Shepherd PR. Smith GC, et al. Among authors: rewcastle gw. FEBS J. 2013 Nov;280(21):5337-49. doi: 10.1111/febs.12428. Epub 2013 Aug 12. FEBS J. 2013. PMID: 23837532 Free article.

9

Evidence for a role for the p110-alpha isoform of PI3K in skeletal function.

Grey A, Chaussade C, Empson V, Lin JM, Watson M, O'Sullivan S, Rewcastle G, Naot D, Cornish J, Shepherd P. Grey A, et al. Biochem Biophys Res Commun. 2010 Jan 1;391(1):564-9. doi: 10.1016/j.bbrc.2009.11.099. Epub 2009 Nov 24. Biochem Biophys Res Commun. 2010. PMID: 19931507

10

Biological characterization of SN32976, a selective inhibitor of PI3K and mTOR with preferential activity to PI3Kα, in comparison to established pan PI3K inhibitors.

Rewcastle GW, Kolekar S, Buchanan CM, Gamage SA, Giddens AC, Tsang KY, Kendall JD, Singh R, Lee WJ, Smith GC, Han W, Matthews DJ, Denny WA, Shepherd PR, Jamieson SMF. Rewcastle GW, et al. Oncotarget. 2017 Jul 18;8(29):47725-47740. doi: 10.18632/oncotarget.17730. Oncotarget. 2017. PMID: 28537878 Free PMC article.

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