Rewcastle GW - Search Results

1

Orthogonal assays for the identification of inhibitors of the single-stranded nucleic acid binding protein YB-1.

Trevarton A, Zhou Y, Yang D, Rewcastle GW, Flanagan JU, Braithwaite A, Shepherd PR, Print CG, Wang MW, Lasham A. Trevarton A, et al. Among authors: rewcastle gw. Acta Pharm Sin B. 2019 Sep;9(5):997-1007. doi: 10.1016/j.apsb.2018.12.011. Epub 2019 Jan 3. Acta Pharm Sin B. 2019. PMID: 31649849 Free PMC article.

2

High-throughput screening campaigns against a PI3Kα isoform bearing the H1047R mutation identified potential inhibitors with novel scaffolds.

Wang J, Gong GQ, Zhou Y, Lee WJ, Buchanan CM, Denny WA, Rewcastle GW, Kendall JD, Dickson JMJ, Flanagan JU, Shepherd PR, Yang DH, Wang MW. Wang J, et al. Among authors: rewcastle gw. Acta Pharmacol Sin. 2018 Nov;39(11):1816-1822. doi: 10.1038/s41401-018-0057-z. Epub 2018 Jul 10. Acta Pharmacol Sin. 2018. PMID: 29991713 Free PMC article.

3

Combining properties of different classes of PI3Kα inhibitors to understand the molecular features that confer selectivity.

Gong GQ, Kendall JD, Dickson JMJ, Rewcastle GW, Buchanan CM, Denny WA, Shepherd PR, Flanagan JU. Gong GQ, et al. Among authors: rewcastle gw. Biochem J. 2017 Jun 26;474(13):2261-2276. doi: 10.1042/BCJ20161098. Biochem J. 2017. PMID: 28526744

4

DMXAA (Vadimezan, ASA404) is a multi-kinase inhibitor targeting VEGFR2 in particular.

Buchanan CM, Shih JH, Astin JW, Rewcastle GW, Flanagan JU, Crosier PS, Shepherd PR. Buchanan CM, et al. Among authors: rewcastle gw. Clin Sci (Lond). 2012 May 1;122(10):449-57. doi: 10.1042/CS20110412. Clin Sci (Lond). 2012. PMID: 22142330

5

Synthesis and Evaluation of Imidazo[1,2-a]pyridine Analogues of the ZSTK474 Class of Phosphatidylinositol 3-Kinase Inhibitors.

Gamage SA, Spicer JA, Tsang KY, O'Connor PD, Flanagan JU, Lee WJ, Dickson JMJ, Shepherd PR, Denny WA, Rewcastle GW. Gamage SA, et al. Among authors: rewcastle gw. Chem Asian J. 2019 Apr 15;14(8):1249-1261. doi: 10.1002/asia.201801762. Epub 2019 Mar 12. Chem Asian J. 2019. PMID: 30714356

6

Diverse mechanisms activate the PI 3-kinase/mTOR pathway in melanomas: implications for the use of PI 3-kinase inhibitors to overcome resistance to inhibitors of BRAF and MEK.

Tran KB, Kolekar S, Jabed A, Jaynes P, Shih JH, Wang Q, Flanagan JU, Rewcastle GW, Baguley BC, Shepherd PR. Tran KB, et al. Among authors: rewcastle gw. BMC Cancer. 2021 Feb 6;21(1):136. doi: 10.1186/s12885-021-07826-4. BMC Cancer. 2021. PMID: 33549048 Free PMC article.

7

Exploring the isoform selectivity of TGX-221 related pyrido[1,2-a]pyrimidinone-based Class IA PI 3-kinase inhibitors: synthesis, biological evaluation and molecular modelling.

Marshall AJ, Lill CL, Chao M, Kolekar SV, Lee WJ, Marshall ES, Baguley BC, Shepherd PR, Denny WA, Flanagan JU, Rewcastle GW. Marshall AJ, et al. Among authors: rewcastle gw. Bioorg Med Chem. 2015 Jul 1;23(13):3796-808. doi: 10.1016/j.bmc.2015.03.073. Epub 2015 Apr 4. Bioorg Med Chem. 2015. PMID: 25890698

8

A drug targeting only p110α can block phosphoinositide 3-kinase signalling and tumour growth in certain cell types.

Jamieson S, Flanagan JU, Kolekar S, Buchanan C, Kendall JD, Lee WJ, Rewcastle GW, Denny WA, Singh R, Dickson J, Baguley BC, Shepherd PR. Jamieson S, et al. Among authors: rewcastle gw. Biochem J. 2011 Aug 15;438(1):53-62. doi: 10.1042/BJ20110502. Biochem J. 2011. PMID: 21668414 Free PMC article.

9

Functional differences between two classes of oncogenic mutation in the PIK3CA gene.

Chaussade C, Cho K, Mawson C, Rewcastle GW, Shepherd PR. Chaussade C, et al. Among authors: rewcastle gw. Biochem Biophys Res Commun. 2009 Apr 17;381(4):577-81. doi: 10.1016/j.bbrc.2009.02.081. Epub 2009 Feb 20. Biochem Biophys Res Commun. 2009. PMID: 19233141

10

Phosphoinositide-3-kinase (PI3K) inhibitors: identification of new scaffolds using virtual screening.

Frédérick R, Mawson C, Kendall JD, Chaussade C, Rewcastle GW, Shepherd PR, Denny WA. Frédérick R, et al. Among authors: rewcastle gw. Bioorg Med Chem Lett. 2009 Oct 15;19(20):5842-7. doi: 10.1016/j.bmcl.2009.08.087. Epub 2009 Aug 29. Bioorg Med Chem Lett. 2009. PMID: 19748269

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