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Sphingosine-1-phosphate promotes erythrocyte glycolysis and oxygen release for adaptation to high-altitude hypoxia.
Sun K, Zhang Y, D'Alessandro A, Nemkov T, Song A, Wu H, Liu H, Adebiyi M, Huang A, Wen YE, Bogdanov MV, Vila A, O'Brien J, Kellems RE, Dowhan W, Subudhi AW, Jameson-Van Houten S, Julian CG, Lovering AT, Safo M, Hansen KC, Roach RC, Xia Y. Sun K, et al. Nat Commun. 2016 Jul 15;7:12086. doi: 10.1038/ncomms12086. Nat Commun. 2016. PMID: 27417539 Free PMC article.
Beneficial Role of Erythrocyte Adenosine A2B Receptor-Mediated AMP-Activated Protein Kinase Activation in High-Altitude Hypoxia.
Liu H, Zhang Y, Wu H, D'Alessandro A, Yegutkin GG, Song A, Sun K, Li J, Cheng NY, Huang A, Edward Wen Y, Weng TT, Luo F, Nemkov T, Sun H, Kellems RE, Karmouty-Quintana H, Hansen KC, Zhao B, Subudhi AW, Jameson-Van Houten S, Julian CG, Lovering AT, Eltzschig HK, Blackburn MR, Roach RC, Xia Y. Liu H, et al. Among authors: roach rc. Circulation. 2016 Aug 2;134(5):405-21. doi: 10.1161/CIRCULATIONAHA.116.021311. Circulation. 2016. PMID: 27482003 Free PMC article.
Erythrocyte purinergic signaling components underlie hypoxia adaptation.
Sun K, Liu H, Song A, Manalo JM, D'Alessandro A, Hansen KC, Kellems RE, Eltzschig HK, Blackburn MR, Roach RC, Xia Y. Sun K, et al. Among authors: roach rc. J Appl Physiol (1985). 2017 Oct 1;123(4):951-956. doi: 10.1152/japplphysiol.00155.2017. Epub 2017 Jun 1. J Appl Physiol (1985). 2017. PMID: 28572494 Free PMC article. Review.
Erythrocytes retain hypoxic adenosine response for faster acclimatization upon re-ascent.
Song A, Zhang Y, Han L, Yegutkin GG, Liu H, Sun K, D'Alessandro A, Li J, Karmouty-Quintana H, Iriyama T, Weng T, Zhao S, Wang W, Wu H, Nemkov T, Subudhi AW, Jameson-Van Houten S, Julian CG, Lovering AT, Hansen KC, Zhang H, Bogdanov M, Dowhan W, Jin J, Kellems RE, Eltzschig HK, Blackburn M, Roach RC, Xia Y. Song A, et al. Nat Commun. 2017 Feb 7;8:14108. doi: 10.1038/ncomms14108. Nat Commun. 2017. PMID: 28169986 Free PMC article.
Hypoxia modulates the purine salvage pathway and decreases red blood cell and supernatant levels of hypoxanthine during refrigerated storage.
Nemkov T, Sun K, Reisz JA, Song A, Yoshida T, Dunham A, Wither MJ, Francis RO, Roach RC, Dzieciatkowska M, Rogers SC, Doctor A, Kriebardis A, Antonelou M, Papassideri I, Young CT, Thomas TA, Hansen KC, Spitalnik SL, Xia Y, Zimring JC, Hod EA, D'Alessandro A. Nemkov T, et al. Haematologica. 2018 Feb;103(2):361-372. doi: 10.3324/haematol.2017.178608. Epub 2017 Oct 27. Haematologica. 2018. PMID: 29079593 Free PMC article.
AltitudeOmics: Red Blood Cell Metabolic Adaptation to High Altitude Hypoxia.
D'Alessandro A, Nemkov T, Sun K, Liu H, Song A, Monte AA, Subudhi AW, Lovering AT, Dvorkin D, Julian CG, Kevil CG, Kolluru GK, Shiva S, Gladwin MT, Xia Y, Hansen KC, Roach RC. D'Alessandro A, et al. J Proteome Res. 2016 Oct 7;15(10):3883-3895. doi: 10.1021/acs.jproteome.6b00733. Epub 2016 Sep 27. J Proteome Res. 2016. PMID: 27646145 Free PMC article.
Translation in progress: hypoxia.
Roach RC, Wagner PD, Hackett PH. Roach RC, et al. J Appl Physiol (1985). 2014 Apr 1;116(7):835-6. doi: 10.1152/japplphysiol.00145.2014. Epub 2014 Feb 20. J Appl Physiol (1985). 2014. PMID: 24557798 Free article. No abstract available.
303 results