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Bioprinted 3D outer retina barrier uncovers RPE-dependent choroidal phenotype in advanced macular degeneration.
Song MJ, Quinn R, Nguyen E, Hampton C, Sharma R, Park TS, Koster C, Voss T, Tristan C, Weber C, Singh A, Dejene R, Bose D, Chen YC, Derr P, Derr K, Michael S, Barone F, Chen G, Boehm M, Maminishkis A, Singec I, Ferrer M, Bharti K. Song MJ, et al. Among authors: dejene r. Nat Methods. 2023 Jan;20(1):149-161. doi: 10.1038/s41592-022-01701-1. Epub 2022 Dec 22. Nat Methods. 2023. PMID: 36550275
Clinical-grade stem cell-derived retinal pigment epithelium patch rescues retinal degeneration in rodents and pigs.
Sharma R, Khristov V, Rising A, Jha BS, Dejene R, Hotaling N, Li Y, Stoddard J, Stankewicz C, Wan Q, Zhang C, Campos MM, Miyagishima KJ, McGaughey D, Villasmil R, Mattapallil M, Stanzel B, Qian H, Wong W, Chase L, Charles S, McGill T, Miller S, Maminishkis A, Amaral J, Bharti K. Sharma R, et al. Among authors: dejene r. Sci Transl Med. 2019 Jan 16;11(475):eaat5580. doi: 10.1126/scitranslmed.aat5580. Sci Transl Med. 2019. PMID: 30651323 Free PMC article.
Epithelial phenotype restoring drugs suppress macular degeneration phenotypes in an iPSC model.
Sharma R, George A, Nimmagadda M, Ortolan D, Karla BS, Qureshy Z, Bose D, Dejene R, Liang G, Wan Q, Chang J, Jha BS, Memon O, Miyagishima KJ, Rising A, Lal M, Hanson E, King R, Campos MM, Ferrer M, Amaral J, McGaughey D, Bharti K. Sharma R, et al. Among authors: dejene r. Nat Commun. 2021 Dec 15;12(1):7293. doi: 10.1038/s41467-021-27488-x. Nat Commun. 2021. PMID: 34911940 Free PMC article.
Primary Cilium-Mediated Retinal Pigment Epithelium Maturation Is Disrupted in Ciliopathy Patient Cells.
May-Simera HL, Wan Q, Jha BS, Hartford J, Khristov V, Dejene R, Chang J, Patnaik S, Lu Q, Banerjee P, Silver J, Insinna-Kettenhofen C, Patel D, Lotfi M, Malicdan M, Hotaling N, Maminishkis A, Sridharan R, Brooks B, Miyagishima K, Gunay-Aygun M, Pal R, Westlake C, Miller S, Sharma R, Bharti K. May-Simera HL, et al. Among authors: dejene r. Cell Rep. 2018 Jan 2;22(1):189-205. doi: 10.1016/j.celrep.2017.12.038. Cell Rep. 2018. PMID: 29298421 Free PMC article.
Regulation of phagolysosomal activity by miR-204 critically influences structure and function of retinal pigment epithelium/retina.
Zhang C, Miyagishima KJ, Dong L, Rising A, Nimmagadda M, Liang G, Sharma R, Dejene R, Wang Y, Abu-Asab M, Qian H, Li Y, Kopera M, Maminishkis A, Martinez J, Miller S. Zhang C, et al. Among authors: dejene r. Hum Mol Genet. 2019 Oct 15;28(20):3355-3368. doi: 10.1093/hmg/ddz171. Hum Mol Genet. 2019. PMID: 31332443 Free PMC article.