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Spinal and bulbar muscular atrophy: From molecular pathogenesis to pharmacological intervention targeting skeletal muscle.
Curr Opin Pharmacol. 2023 Aug;71:102394. doi: 10.1016/j.coph.2023.102394. Epub 2023 Jul 16.
Curr Opin Pharmacol. 2023.
PMID: 37463556
Free article.
Review.
Defective excitation-contraction coupling and mitochondrial respiration precede mitochondrial Ca2+ accumulation in spinobulbar muscular atrophy skeletal muscle.
Marchioretti C, Zanetti G, Pirazzini M, Gherardi G, Nogara L, Andreotti R, Martini P, Marcucci L, Canato M, Nath SR, Zuccaro E, Chivet M, Mammucari C, Pacifici M, Raffaello A, Rizzuto R, Mattarei A, Desbats MA, Salviati L, Megighian A, Sorarù G, Pegoraro E, Belluzzi E, Pozzuoli A, Biz C, Ruggieri P, Romualdi C, Lieberman AP, Babu GJ, Sandri M, Blaauw B, Basso M, Pennuto M.
Marchioretti C, et al. Among authors: andreotti r.
Nat Commun. 2023 Feb 6;14(1):602. doi: 10.1038/s41467-023-36185-w.
Nat Commun. 2023.
PMID: 36746942
Free PMC article.
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LSD1/PRMT6-targeting gene therapy to attenuate androgen receptor toxic gain-of-function ameliorates spinobulbar muscular atrophy phenotypes in flies and mice.
Prakasam R, Bonadiman A, Andreotti R, Zuccaro E, Dalfovo D, Marchioretti C, Tripathy D, Petris G, Anderson EN, Migazzi A, Tosatto L, Cereseto A, Battaglioli E, Sorarù G, Lim WF, Rinaldi C, Sambataro F, Pourshafie N, Grunseich C, Romanel A, Pandey UB, Contestabile A, Ronzitti G, Basso M, Pennuto M.
Prakasam R, et al. Among authors: andreotti r.
Nat Commun. 2023 Feb 6;14(1):603. doi: 10.1038/s41467-023-36186-9.
Nat Commun. 2023.
PMID: 36746939
Free PMC article.
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Secreted Metabolome of ALS-Related hSOD1(G93A) Primary Cultures of Myocytes and Implications for Myogenesis.
Stella R, Bonadio RS, Cagnin S, Andreotti R, Massimino ML, Bertoli A, Peggion C.
Stella R, et al. Among authors: andreotti r.
Cells. 2023 Nov 30;12(23):2751. doi: 10.3390/cells12232751.
Cells. 2023.
PMID: 38067180
Free PMC article.
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