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ONC201 and imipridones: Anti-cancer compounds with clinical efficacy.
Prabhu VV, Morrow S, Rahman Kawakibi A, Zhou L, Ralff M, Ray J, Jhaveri A, Ferrarini I, Lee Y, Parker C, Zhang Y, Borsuk R, Chang WI, Honeyman JN, Tavora F, Carneiro B, Raufi A, Huntington K, Carlsen L, Louie A, Safran H, Seyhan AA, Tarapore RS, Schalop L, Stogniew M, Allen JE, Oster W, El-Deiry WS. Prabhu VV, et al. Among authors: borsuk r. Neoplasia. 2020 Dec;22(12):725-744. doi: 10.1016/j.neo.2020.09.005. Epub 2020 Oct 23. Neoplasia. 2020. PMID: 33142238 Free PMC article. Review.
Lead Exposure in Newly Resettled Pediatric Refugees in Syracuse, NY.
Lupone CD, Daniels D, Lammert D, Borsuk R, Hobart T, Lane S, Shaw A. Lupone CD, et al. Among authors: borsuk r. J Immigr Minor Health. 2020 Feb;22(1):34-43. doi: 10.1007/s10903-019-00880-y. J Immigr Minor Health. 2020. PMID: 30895418 Free PMC article.
EZH2i EPZ-6438 and HDACi vorinostat synergize with ONC201/TIC10 to activate integrated stress response, DR5, reduce H3K27 methylation, ClpX and promote apoptosis of multiple tumor types including DIPG.
Zhang Y, Zhou L, Safran H, Borsuk R, Lulla R, Tapinos N, Seyhan AA, El-Deiry WS. Zhang Y, et al. Among authors: borsuk r. Neoplasia. 2021 Aug;23(8):792-810. doi: 10.1016/j.neo.2021.06.007. Epub 2021 Jul 8. Neoplasia. 2021. PMID: 34246076 Free PMC article.
Potent preclinical sensitivity to imipridone-based combination therapies in oncohistone H3K27M-mutant diffuse intrinsic pontine glioma is associated with induction of the integrated stress response, TRAIL death receptor DR5, reduced ClpX and apoptosis.
Borsuk R, Zhou L, Chang WI, Zhang Y, Sharma A, Prabhu VV, Tapinos N, Lulla RR, El-Deiry WS. Borsuk R, et al. Am J Cancer Res. 2021 Sep 15;11(9):4607-4623. eCollection 2021. Am J Cancer Res. 2021. PMID: 34659909 Free PMC article.