Roczniak S - Search Results

1

Selective alteration of substrate specificity by replacement of aspartic acid-189 with lysine in the binding pocket of trypsin.

Graf L, Craik CS, Patthy A, Roczniak S, Fletterick RJ, Rutter WJ. Graf L, et al. Among authors: roczniak s. Biochemistry. 1987 May 5;26(9):2616-23. doi: 10.1021/bi00383a031. Biochemistry. 1987. PMID: 3111531

2

Redesigning trypsin via genetic engineering.

Craik CS, Roczniak S, Sprang S, Fletterick R, Rutter W. Craik CS, et al. Among authors: roczniak s. J Cell Biochem. 1987 Mar;33(3):199-211. doi: 10.1002/jcb.240330307. J Cell Biochem. 1987. PMID: 3553217 Review. No abstract available.

3

Redesigning trypsin: alteration of substrate specificity.

Craik CS, Largman C, Fletcher T, Roczniak S, Barr PJ, Fletterick R, Rutter WJ. Craik CS, et al. Among authors: roczniak s. Science. 1985 Apr 19;228(4697):291-7. doi: 10.1126/science.3838593. Science. 1985. PMID: 3838593

4

The catalytic role of the active site aspartic acid in serine proteases.

Craik CS, Roczniak S, Largman C, Rutter WJ. Craik CS, et al. Among authors: roczniak s. Science. 1987 Aug 21;237(4817):909-13. doi: 10.1126/science.3303334. Science. 1987. PMID: 3303334

5

A kinetic study of interactions of (Rp)- and (Sp)-adenosine cyclic 3',5'-phosphorothioates with type II bovine cardiac muscle adenosine cyclic 3',5'-phosphate dependent protein kinase.

O'Brian CA, Roczniak SO, Bramson HN, Baraniak J, Stec WJ, Kaiser ET. O'Brian CA, et al. Among authors: roczniak so. Biochemistry. 1982 Aug 31;21(18):4371-6. doi: 10.1021/bi00261a028. Biochemistry. 1982. PMID: 6289880

6

Generation of PEGylated VPAC1-selective antagonists that inhibit proliferation of a lung cancer cell line.

Pan CQ, Hamren S, Roczniak S, Tom I, DeRome M. Pan CQ, et al. Among authors: roczniak s. Peptides. 2008 Mar;29(3):479-86. doi: 10.1016/j.peptides.2007.09.003. Epub 2007 Sep 12. Peptides. 2008. PMID: 17942192

7

Dual-acting peptide with prolonged glucagon-like peptide-1 receptor agonist and glucagon receptor antagonist activity for the treatment of type 2 diabetes.

Claus TH, Pan CQ, Buxton JM, Yang L, Reynolds JC, Barucci N, Burns M, Ortiz AA, Roczniak S, Livingston JN, Clairmont KB, Whelan JP. Claus TH, et al. Among authors: roczniak s. J Endocrinol. 2007 Feb;192(2):371-80. doi: 10.1677/JOE-06-0018. J Endocrinol. 2007. PMID: 17283237

8

Engineering novel VPAC2-selective agonists with improved stability and glucose-lowering activity in vivo.

Pan CQ, Li F, Tom I, Wang W, Dumas M, Froland W, Yung SL, Li Y, Roczniak S, Claus TH, Wang YJ, Whelan JP. Pan CQ, et al. Among authors: roczniak s. J Pharmacol Exp Ther. 2007 Feb;320(2):900-6. doi: 10.1124/jpet.106.112276. Epub 2006 Nov 16. J Pharmacol Exp Ther. 2007. PMID: 17110523

9

Generation of highly selective VPAC2 receptor agonists by high throughput mutagenesis of vasoactive intestinal peptide and pituitary adenylate cyclase-activating peptide.

Yung SL, Dela Cruz F, Hamren S, Zhu J, Tsutsumi M, Bloom JW, Caudle M, Roczniak S, Todd T, Lemoine L, MacDougall M, Shanafelt AB, Pan CQ. Yung SL, et al. Among authors: roczniak s. J Biol Chem. 2003 Mar 21;278(12):10273-81. doi: 10.1074/jbc.M211945200. Epub 2003 Jan 13. J Biol Chem. 2003. PMID: 12525492 Free article.

10

A T-cell-selective interleukin 2 mutein exhibits potent antitumor activity and is well tolerated in vivo.

Shanafelt AB, Lin Y, Shanafelt MC, Forte CP, Dubois-Stringfellow N, Carter C, Gibbons JA, Cheng SL, Delaria KA, Fleischer R, Greve JM, Gundel R, Harris K, Kelly R, Koh B, Li Y, Lantz L, Mak P, Neyer L, Plym MJ, Roczniak S, Serban D, Thrift J, Tsuchiyama L, Wetzel M, Wong M, Zolotorev A. Shanafelt AB, et al. Among authors: roczniak s. Nat Biotechnol. 2000 Nov;18(11):1197-202. doi: 10.1038/81199. Nat Biotechnol. 2000. PMID: 11062441

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