Roda A - Search Results

1

Discovery of 6alpha-ethyl-23(S)-methylcholic acid (S-EMCA, INT-777) as a potent and selective agonist for the TGR5 receptor, a novel target for diabesity.

Pellicciari R, Gioiello A, Macchiarulo A, Thomas C, Rosatelli E, Natalini B, Sardella R, Pruzanski M, Roda A, Pastorini E, Schoonjans K, Auwerx J. Pellicciari R, et al. Among authors: roda a. J Med Chem. 2009 Dec 24;52(24):7958-61. doi: 10.1021/jm901390p. J Med Chem. 2009. PMID: 20014870

2

Avicholic Acid: A Lead Compound from Birds on the Route to Potent TGR5 Modulators.

Pellicciari R, Gioiello A, Sabbatini P, Venturoni F, Nuti R, Colliva C, Rizzo G, Adorini L, Pruzanski M, Roda A, Macchiarulo A. Pellicciari R, et al. Among authors: roda a. ACS Med Chem Lett. 2012 Feb 6;3(4):273-7. doi: 10.1021/ml200256d. eCollection 2012 Apr 12. ACS Med Chem Lett. 2012. PMID: 24900463 Free PMC article.

3

Discovery of 3α,7α,11β-Trihydroxy-6α-ethyl-5β-cholan-24-oic Acid (TC-100), a Novel Bile Acid as Potent and Highly Selective FXR Agonist for Enterohepatic Disorders.

Pellicciari R, Passeri D, De Franco F, Mostarda S, Filipponi P, Colliva C, Gadaleta RM, Franco P, Carotti A, Macchiarulo A, Roda A, Moschetta A, Gioiello A. Pellicciari R, et al. Among authors: roda a. J Med Chem. 2016 Oct 13;59(19):9201-9214. doi: 10.1021/acs.jmedchem.6b01126. Epub 2016 Oct 4. J Med Chem. 2016. PMID: 27652492

4

Semisynthetic bile acid FXR and TGR5 agonists: physicochemical properties, pharmacokinetics, and metabolism in the rat.

Roda A, Pellicciari R, Gioiello A, Neri F, Camborata C, Passeri D, De Franco F, Spinozzi S, Colliva C, Adorini L, Montagnani M, Aldini R. Roda A, et al. J Pharmacol Exp Ther. 2014 Jul;350(1):56-68. doi: 10.1124/jpet.114.214650. Epub 2014 May 1. J Pharmacol Exp Ther. 2014. PMID: 24784847

5

Bile acids with a cyclopropyl-containing side chain. 3. Separation, identification, and properties of all four stereoisomers of 3 alpha,7 beta-dihydroxy-22,23-methylene-5 beta-cholan-24-oic acid.

Pellicciari R, Natalini B, Cecchetti S, Porter B, Roda A, Grigolo B, Balducci R. Pellicciari R, et al. Among authors: roda a. J Med Chem. 1988 Apr;31(4):730-6. doi: 10.1021/jm00399a007. J Med Chem. 1988. PMID: 3351848

6

23-Methyl-3 alpha,7 beta-dihydroxy-5 beta-cholan-24-oic acid: dose-response study of biliary secretion in rat.

Roda A, Aldini R, Grigolo B, Simoni P, Roda E, Pellicciari R, Lenzi PL, Natalini B. Roda A, et al. Among authors: roda e. Hepatology. 1988 Nov-Dec;8(6):1571-6. doi: 10.1002/hep.1840080617. Hepatology. 1988. PMID: 3192170

7

Physicochemical and biological properties of natural and synthetic C-22 and C-23 hydroxylated bile acids.

Roda A, Grigolo B, Minutello A, Pellicciari R, Natalini B. Roda A, et al. J Lipid Res. 1990 Feb;31(2):289-98. J Lipid Res. 1990. PMID: 2324648 Free article.

8

Structure-activity relationship studies on natural and synthetic bile acid analogs.

Roda A, Grigolo B, Pellicciari R, Natalini B. Roda A, et al. Dig Dis Sci. 1989 Dec;34(12 Suppl):24S-35S. doi: 10.1007/BF01536659. Dig Dis Sci. 1989. PMID: 2598765

9

Bile acids with cyclopropane-containing side chain. 2. Synthesis and properties of 3 alpha,7 beta-dihydroxy-22,23-methylene-5 beta-cholan-24-oic acid (2-sulfoethyl)amide.

Pellicciari R, Cecchetti S, Natalini B, Roda A, Grigolo B, Fini A. Pellicciari R, et al. Among authors: roda a. J Med Chem. 1985 Feb;28(2):239-42. doi: 10.1021/jm00380a015. J Med Chem. 1985. PMID: 3968688

10

Bile acids with a cyclopropyl-containing side chain. 1. Preparation and properties of 3 alpha, 7 beta-dihydroxy-22,23-methylene-5 beta-cholan-24-oic acid.

Pellicciari R, Cecchetti S, Natalini B, Roda A, Grigolo B, Fini A. Pellicciari R, et al. Among authors: roda a. J Med Chem. 1984 Jun;27(6):746-9. doi: 10.1021/jm00372a007. J Med Chem. 1984. PMID: 6737415

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