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Patient-specific iPSCs carrying an SFTPC mutation reveal the intrinsic alveolar epithelial dysfunction at the inception of interstitial lung disease.
Alysandratos KD, Russo SJ, Petcherski A, Taddeo EP, Acín-Pérez R, Villacorta-Martin C, Jean JC, Mulugeta S, Rodriguez LR, Blum BC, Hekman RM, Hix OT, Minakin K, Vedaie M, Kook S, Tilston-Lunel AM, Varelas X, Wambach JA, Cole FS, Hamvas A, Young LR, Liesa M, Emili A, Guttentag SH, Shirihai OS, Beers MF, Kotton DN. Alysandratos KD, et al. Among authors: rodriguez lr. Cell Rep. 2021 Aug 31;36(9):109636. doi: 10.1016/j.celrep.2021.109636. Cell Rep. 2021. PMID: 34469722 Free PMC article.
The common ABCA3E292V variant disrupts AT2 cell quality control and increases susceptibility to lung injury and aberrant remodeling.
Tomer Y, Wambach J, Knudsen L, Zhao M, Rodriguez LR, Murthy A, White FV, Venosa A, Katzen J, Ochs M, Hamvas A, Beers MF, Mulugeta S. Tomer Y, et al. Among authors: rodriguez lr. Am J Physiol Lung Cell Mol Physiol. 2021 Aug 1;321(2):L291-L307. doi: 10.1152/ajplung.00400.2020. Epub 2021 Jun 16. Am J Physiol Lung Cell Mol Physiol. 2021. PMID: 34132118 Free PMC article.
Disruption of proteostasis causes IRE1 mediated reprogramming of alveolar epithelial cells.
Katzen J, Rodriguez L, Tomer Y, Babu A, Zhao M, Murthy A, Carson P, Barrett M, Basil MC, Carl J, Leach JP, Morley M, McGraw MD, Mulugeta S, Pelura T, Rosen G, Morrisey EE, Beers MF. Katzen J, et al. Proc Natl Acad Sci U S A. 2022 Oct 25;119(43):e2123187119. doi: 10.1073/pnas.2123187119. Epub 2022 Oct 17. Proc Natl Acad Sci U S A. 2022. PMID: 36252035 Free PMC article.
Disruption of Prostaglandin F2α Receptor Signaling Attenuates Fibrotic Remodeling and Alters Fibroblast Population Dynamics in A Preclinical Murine Model of Idiopathic Pulmonary Fibrosis.
Rodriguez LR, Tang SY, Barboza WR, Murthy A, Tomer Y, Cai TQ, Iyer S, Chavez K, Das US, Ghosh S, Dimopoulos T, Babu A, Connelly C, FitzGerald GA, Beers MF. Rodriguez LR, et al. bioRxiv [Preprint]. 2023 Jun 7:2023.06.07.543956. doi: 10.1101/2023.06.07.543956. bioRxiv. 2023. PMID: 37333249 Free PMC article. Preprint.
PGF2α signaling drives fibrotic remodeling and fibroblast population dynamics in mice.
Rodriguez LR, Tang SY, Roque Barboza W, Murthy A, Tomer Y, Cai TQ, Iyer S, Chavez K, Das US, Ghosh S, Cooper CH, Dimopoulos TT, Babu A, Connelly C, FitzGerald GA, Beers MF. Rodriguez LR, et al. JCI Insight. 2023 Dec 22;8(24):e172977. doi: 10.1172/jci.insight.172977. JCI Insight. 2023. PMID: 37934604 Free PMC article.
Impaired AMPK Control of Alveolar Epithelial Cell Metabolism Promotes Pulmonary Fibrosis.
Rodriguez LR, Alysandratos KD, Katzen J, Murthy A, Barboza WR, Tomer Y, Acin-Perez R, Petcherski A, Minakin K, Carson P, Iyer S, Chavez K, Cooper CH, Babu A, Weiner AI, Vaughan AE, Arany Z, Shirihai OS, Kotton DN, Beers MF. Rodriguez LR, et al. bioRxiv [Preprint]. 2024 Mar 28:2024.03.26.586649. doi: 10.1101/2024.03.26.586649. bioRxiv. 2024. PMID: 38585863 Free PMC article. Preprint.
Incidence and clinical manifestations of giant cell arteritis in Spain: results of the ARTESER register.
Fernández-Lozano D, Hernández-Rodríguez I, Narvaez J, Domínguez-Álvaro M, De Miguel E, Silva-Díaz M, Belzunegui JM, Moriano Morales C, Sánchez J, Galíndez-Agirregoikoa E, Aldaroso V, Abasolo L, Loricera J, Garrido-Puñal N, Moya Alvarado P, Larena C, Navarro VA, Calvet J, Casafont-Solé I, Ortiz-Sanjuán F, Salman Monte TC, Castañeda S, Blanco R; ARTESER Project Collaborative Group. Fernández-Lozano D, et al. RMD Open. 2024 Mar 26;10(1):e003824. doi: 10.1136/rmdopen-2023-003824. RMD Open. 2024. PMID: 38531620 Free PMC article.
48 results