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Development of small-molecule inhibitors targeting adipose triglyceride lipase.
Mayer N, Schweiger M, Romauch M, Grabner GF, Eichmann TO, Fuchs E, Ivkovic J, Heier C, Mrak I, Lass A, Höfler G, Fledelius C, Zechner R, Zimmermann R, Breinbauer R. Mayer N, et al. Among authors: romauch m. Nat Chem Biol. 2013 Dec;9(12):785-7. doi: 10.1038/nchembio.1359. Epub 2013 Oct 6. Nat Chem Biol. 2013. PMID: 24096302 Free PMC article.
α/β Hydrolase Domain-containing 6 (ABHD6) Degrades the Late Endosomal/Lysosomal Lipid Bis(monoacylglycero)phosphate.
Pribasnig MA, Mrak I, Grabner GF, Taschler U, Knittelfelder O, Scherz B, Eichmann TO, Heier C, Grumet L, Kowaliuk J, Romauch M, Holler S, Anderl F, Wolinski H, Lass A, Breinbauer R, Marsche G, Brown JM, Zimmermann R. Pribasnig MA, et al. Among authors: romauch m. J Biol Chem. 2015 Dec 11;290(50):29869-81. doi: 10.1074/jbc.M115.669168. Epub 2015 Oct 21. J Biol Chem. 2015. PMID: 26491015 Free PMC article.
Adipose triglyceride lipase is involved in the mobilization of triglyceride and retinoid stores of hepatic stellate cells.
Taschler U, Schreiber R, Chitraju C, Grabner GF, Romauch M, Wolinski H, Haemmerle G, Breinbauer R, Zechner R, Lass A, Zimmermann R. Taschler U, et al. Among authors: romauch m. Biochim Biophys Acta. 2015 Jul;1851(7):937-45. doi: 10.1016/j.bbalip.2015.02.017. Epub 2015 Feb 27. Biochim Biophys Acta. 2015. PMID: 25732851 Free PMC article.
Pharmacological inhibition of adipose triglyceride lipase corrects high-fat diet-induced insulin resistance and hepatosteatosis in mice.
Schweiger M, Romauch M, Schreiber R, Grabner GF, Hütter S, Kotzbeck P, Benedikt P, Eichmann TO, Yamada S, Knittelfelder O, Diwoky C, Doler C, Mayer N, De Cecco W, Breinbauer R, Zimmermann R, Zechner R. Schweiger M, et al. Among authors: romauch m. Nat Commun. 2017 Mar 22;8:14859. doi: 10.1038/ncomms14859. Nat Commun. 2017. PMID: 28327588 Free PMC article.
Lysosomal Acid Lipase Hydrolyzes Retinyl Ester and Affects Retinoid Turnover.
Grumet L, Eichmann TO, Taschler U, Zierler KA, Leopold C, Moustafa T, Radovic B, Romauch M, Yan C, Du H, Haemmerle G, Zechner R, Fickert P, Kratky D, Zimmermann R, Lass A. Grumet L, et al. Among authors: romauch m. J Biol Chem. 2016 Aug 19;291(34):17977-87. doi: 10.1074/jbc.M116.724054. Epub 2016 Jun 27. J Biol Chem. 2016. PMID: 27354281 Free PMC article.
Corrigendum: Pharmacological inhibition of adipose triglyceride lipase corrects high-fat diet-induced insulin resistance and hepatosteatosis in mice.
Schweiger M, Romauch M, Schreiber R, Grabner GF, Hütter S, Kotzbeck P, Benedikt P, Eichmann TO, Yamada S, Knittelfelder O, Diwoky C, Doler C, Mayer N, De Cecco W, Breinbauer R, Zimmermann R, Zechner R. Schweiger M, et al. Among authors: romauch m. Nat Commun. 2017 Apr 25;8:15490. doi: 10.1038/ncomms15490. Nat Commun. 2017. PMID: 28440272 Free PMC article. No abstract available.
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