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Mitochondrial damage activates the NLRP10 inflammasome.
Próchnicki T, Vasconcelos MB, Robinson KS, Mangan MSJ, De Graaf D, Shkarina K, Lovotti M, Standke L, Kaiser R, Stahl R, Duthie FG, Rothe M, Antonova K, Jenster LM, Lau ZH, Rösing S, Mirza N, Gottschild C, Wachten D, Günther C, Kufer TA, Schmidt FI, Zhong FL, Latz E. Próchnicki T, et al. Among authors: kaiser r. Nat Immunol. 2023 Apr;24(4):595-603. doi: 10.1038/s41590-023-01451-y. Epub 2023 Mar 20. Nat Immunol. 2023. PMID: 36941400
Toll-like Receptor Signaling Rewires Macrophage Metabolism and Promotes Histone Acetylation via ATP-Citrate Lyase.
Lauterbach MA, Hanke JE, Serefidou M, Mangan MSJ, Kolbe CC, Hess T, Rothe M, Kaiser R, Hoss F, Gehlen J, Engels G, Kreutzenbeck M, Schmidt SV, Christ A, Imhof A, Hiller K, Latz E. Lauterbach MA, et al. Among authors: kaiser r. Immunity. 2019 Dec 17;51(6):997-1011.e7. doi: 10.1016/j.immuni.2019.11.009. Immunity. 2019. PMID: 31851905 Free article.