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Development and validation of LC-MS/MS methods for the quantification of the novel anticancer agent guadecitabine and its active metabolite β‑decitabine in human plasma, whole blood and urine.
Roosendaal J, Wang K, Rosing H, Lucas L, Gebretensae A, Oganesian A, Schellens JHM, Beijnen JH, Lin ZJ. Roosendaal J, et al. J Chromatogr B Analyt Technol Biomed Life Sci. 2019 Mar 1;1109:132-141. doi: 10.1016/j.jchromb.2019.01.011. Epub 2019 Jan 22. J Chromatogr B Analyt Technol Biomed Life Sci. 2019. PMID: 30754019
Development, validation, and clinical application of a high-performance liquid chromatography-tandem mass spectrometry assay for the quantification of total intracellular β-decitabine nucleotides and genomic DNA incorporated β-decitabine and 5-methyl-2'-deoxycytidine.
Roosendaal J, Rosing H, Lucas L, Oganesian A, Schellens JHM, Beijnen JH. Roosendaal J, et al. J Pharm Biomed Anal. 2019 Feb 5;164:16-26. doi: 10.1016/j.jpba.2018.10.001. Epub 2018 Oct 3. J Pharm Biomed Anal. 2019. PMID: 30366147
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