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TAM receptor signaling and autoimmune disease.
Rothlin CV, Lemke G. Rothlin CV, et al. Curr Opin Immunol. 2010 Dec;22(6):740-6. doi: 10.1016/j.coi.2010.10.001. Epub 2010 Oct 26. Curr Opin Immunol. 2010. PMID: 21030229 Free PMC article. Review.
T cell-derived protein S engages TAM receptor signaling in dendritic cells to control the magnitude of the immune response.
Carrera Silva EA, Chan PY, Joannas L, Errasti AE, Gagliani N, Bosurgi L, Jabbour M, Perry A, Smith-Chakmakova F, Mucida D, Cheroutre H, Burstyn-Cohen T, Leighton JA, Lemke G, Ghosh S, Rothlin CV. Carrera Silva EA, et al. Among authors: rothlin cv. Immunity. 2013 Jul 25;39(1):160-70. doi: 10.1016/j.immuni.2013.06.010. Epub 2013 Jul 11. Immunity. 2013. PMID: 23850380 Free PMC article.
Targeting aPKC disables oncogenic signaling by both the EGFR and the proinflammatory cytokine TNFα in glioblastoma.
Kusne Y, Carrera-Silva EA, Perry AS, Rushing EJ, Mandell EK, Dietrich JD, Errasti AE, Gibbs D, Berens ME, Loftus JC, Hulme C, Yang W, Lu Z, Aldape K, Sanai N, Rothlin CV, Ghosh S. Kusne Y, et al. Among authors: rothlin cv. Sci Signal. 2014 Aug 12;7(338):ra75. doi: 10.1126/scisignal.2005196. Sci Signal. 2014. PMID: 25118327 Free PMC article.
TAM receptor signaling in immune homeostasis.
Rothlin CV, Carrera-Silva EA, Bosurgi L, Ghosh S. Rothlin CV, et al. Annu Rev Immunol. 2015;33:355-91. doi: 10.1146/annurev-immunol-032414-112103. Epub 2015 Jan 14. Annu Rev Immunol. 2015. PMID: 25594431 Free PMC article. Review.
Gas6/Axl pathway is activated in chronic liver disease and its targeting reduces fibrosis via hepatic stellate cell inactivation.
Bárcena C, Stefanovic M, Tutusaus A, Joannas L, Menéndez A, García-Ruiz C, Sancho-Bru P, Marí M, Caballeria J, Rothlin CV, Fernández-Checa JC, de Frutos PG, Morales A. Bárcena C, et al. Among authors: rothlin cv. J Hepatol. 2015 Sep;63(3):670-8. doi: 10.1016/j.jhep.2015.04.013. Epub 2015 Apr 20. J Hepatol. 2015. PMID: 25908269 Free PMC article.
The TAM family receptor tyrosine kinase TYRO3 is a negative regulator of type 2 immunity.
Chan PY, Carrera Silva EA, De Kouchkovsky D, Joannas LD, Hao L, Hu D, Huntsman S, Eng C, Licona-Limón P, Weinstein JS, Herbert DR, Craft JE, Flavell RA, Repetto S, Correale J, Burchard EG, Torgerson DG, Ghosh S, Rothlin CV. Chan PY, et al. Among authors: rothlin cv. Science. 2016 Apr 1;352(6281):99-103. doi: 10.1126/science.aaf1358. Science. 2016. PMID: 27034374 Free PMC article.
TAM receptors regulate multiple features of microglial physiology.
Fourgeaud L, Través PG, Tufail Y, Leal-Bailey H, Lew ED, Burrola PG, Callaway P, Zagórska A, Rothlin CV, Nimmerjahn A, Lemke G. Fourgeaud L, et al. Among authors: rothlin cv. Nature. 2016 Apr 14;532(7598):240-244. doi: 10.1038/nature17630. Epub 2016 Apr 6. Nature. 2016. PMID: 27049947 Free PMC article.
86 results