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Studying human disease using human neurons.
Ahfeldt T, Litterman NK, Rubin LL. Ahfeldt T, et al. Among authors: rubin ll. Brain Res. 2017 Feb 1;1656:40-48. doi: 10.1016/j.brainres.2016.03.051. Epub 2016 Apr 6. Brain Res. 2017. PMID: 27060768 Free PMC article. Review.
A TALEN genome-editing system for generating human stem cell-based disease models.
Ding Q, Lee YK, Schaefer EA, Peters DT, Veres A, Kim K, Kuperwasser N, Motola DL, Meissner TB, Hendriks WT, Trevisan M, Gupta RM, Moisan A, Banks E, Friesen M, Schinzel RT, Xia F, Tang A, Xia Y, Figueroa E, Wann A, Ahfeldt T, Daheron L, Zhang F, Rubin LL, Peng LF, Chung RT, Musunuru K, Cowan CA. Ding Q, et al. Among authors: rubin ll. Cell Stem Cell. 2013 Feb 7;12(2):238-51. doi: 10.1016/j.stem.2012.11.011. Epub 2012 Dec 13. Cell Stem Cell. 2013. PMID: 23246482 Free PMC article.
A small molecule screen in stem-cell-derived motor neurons identifies a kinase inhibitor as a candidate therapeutic for ALS.
Yang YM, Gupta SK, Kim KJ, Powers BE, Cerqueira A, Wainger BJ, Ngo HD, Rosowski KA, Schein PA, Ackeifi CA, Arvanites AC, Davidow LS, Woolf CJ, Rubin LL. Yang YM, et al. Among authors: rubin ll. Cell Stem Cell. 2013 Jun 6;12(6):713-26. doi: 10.1016/j.stem.2013.04.003. Epub 2013 Apr 18. Cell Stem Cell. 2013. PMID: 23602540 Free PMC article.
Modeling pain in vitro using nociceptor neurons reprogrammed from fibroblasts.
Wainger BJ, Buttermore ED, Oliveira JT, Mellin C, Lee S, Saber WA, Wang AJ, Ichida JK, Chiu IM, Barrett L, Huebner EA, Bilgin C, Tsujimoto N, Brenneis C, Kapur K, Rubin LL, Eggan K, Woolf CJ. Wainger BJ, et al. Among authors: rubin ll. Nat Neurosci. 2015 Jan;18(1):17-24. doi: 10.1038/nn.3886. Epub 2014 Nov 24. Nat Neurosci. 2015. PMID: 25420066 Free PMC article.
Creating Patient-Specific Neural Cells for the In Vitro Study of Brain Disorders.
Brennand KJ, Marchetto MC, Benvenisty N, Brüstle O, Ebert A, Izpisua Belmonte JC, Kaykas A, Lancaster MA, Livesey FJ, McConnell MJ, McKay RD, Morrow EM, Muotri AR, Panchision DM, Rubin LL, Sawa A, Soldner F, Song H, Studer L, Temple S, Vaccarino FM, Wu J, Vanderhaeghen P, Gage FH, Jaenisch R. Brennand KJ, et al. Among authors: rubin ll. Stem Cell Reports. 2015 Dec 8;5(6):933-945. doi: 10.1016/j.stemcr.2015.10.011. Epub 2015 Nov 21. Stem Cell Reports. 2015. PMID: 26610635 Free PMC article.
Single-Cell Analysis of SMN Reveals Its Broader Role in Neuromuscular Disease.
Rodriguez-Muela N, Litterman NK, Norabuena EM, Mull JL, Galazo MJ, Sun C, Ng SY, Makhortova NR, White A, Lynes MM, Chung WK, Davidow LS, Macklis JD, Rubin LL. Rodriguez-Muela N, et al. Among authors: rubin ll. Cell Rep. 2017 Feb 7;18(6):1484-1498. doi: 10.1016/j.celrep.2017.01.035. Cell Rep. 2017. PMID: 28178525 Free PMC article.
158 results