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RANK links thymic regulatory T cells to fetal loss and gestational diabetes in pregnancy.
Paolino M, Koglgruber R, Cronin SJF, Uribesalgo I, Rauscher E, Harreiter J, Schuster M, Bancher-Todesca D, Pranjic B, Novatchkova M, Fededa JP, White AJ, Sigl V, Dekan S, Penz T, Bock C, Kenner L, Holländer GA, Anderson G, Kautzky-Willer A, Penninger JM. Paolino M, et al. Among authors: koglgruber r. Nature. 2021 Jan;589(7842):442-447. doi: 10.1038/s41586-020-03071-0. Epub 2020 Dec 23. Nature. 2021. PMID: 33361811 Free PMC article.
The HUSH complex controls brain architecture and protocadherin fidelity.
Hagelkruys A, Horrer M, Taubenschmid-Stowers J, Kavirayani A, Novatchkova M, Orthofer M, Pai TP, Cikes D, Zhuk S, Balmaña M, Esk C, Koglgruber R, Moeseneder P, Lazovic J, Zopf LM, Cronin SJF, Elling U, Knoblich JA, Penninger JM. Hagelkruys A, et al. Among authors: koglgruber r. Sci Adv. 2022 Nov 4;8(44):eabo7247. doi: 10.1126/sciadv.abo7247. Epub 2022 Nov 4. Sci Adv. 2022. PMID: 36332029 Free PMC article.
AIF-regulated oxidative phosphorylation supports lung cancer development.
Rao S, Mondragón L, Pranjic B, Hanada T, Stoll G, Köcher T, Zhang P, Jais A, Lercher A, Bergthaler A, Schramek D, Haigh K, Sica V, Leduc M, Modjtahedi N, Pai TP, Onji M, Uribesalgo I, Hanada R, Kozieradzki I, Koglgruber R, Cronin SJ, She Z, Quehenberger F, Popper H, Kenner L, Haigh JJ, Kepp O, Rak M, Cai K, Kroemer G, Penninger JM. Rao S, et al. Among authors: koglgruber r. Cell Res. 2019 Jul;29(7):579-591. doi: 10.1038/s41422-019-0181-4. Epub 2019 May 27. Cell Res. 2019. PMID: 31133695 Free PMC article.
ACE2 is the critical in vivo receptor for SARS-CoV-2 in a novel COVID-19 mouse model with TNF- and IFNγ-driven immunopathology.
Gawish R, Starkl P, Pimenov L, Hladik A, Lakovits K, Oberndorfer F, Cronin SJ, Ohradanova-Repic A, Wirnsberger G, Agerer B, Endler L, Capraz T, Perthold JW, Cikes D, Koglgruber R, Hagelkruys A, Montserrat N, Mirazimi A, Boon L, Stockinger H, Bergthaler A, Oostenbrink C, Penninger JM, Knapp S. Gawish R, et al. Among authors: koglgruber r. Elife. 2022 Jan 13;11:e74623. doi: 10.7554/eLife.74623. Elife. 2022. PMID: 35023830 Free PMC article.
A crucial role for Jagunal homolog 1 in humoral immunity and antibody glycosylation in mice and humans.
Hagelkruys A, Wirnsberger G, Stadlmann J, Wöhner M, Horrer M, Vilagos B, Jonsson G, Kogler M, Tortola L, Novatchkova M, Bönelt P, Hoffmann D, Koglgruber R, Steffen U, Schett G, Busslinger M, Bergthaler A, Klein C, Penninger JM. Hagelkruys A, et al. Among authors: koglgruber r. J Exp Med. 2021 Jan 4;218(1):e20200559. doi: 10.1084/jem.20200559. J Exp Med. 2021. PMID: 32930709 Free PMC article.
A global in vivo Drosophila RNAi screen identifies NOT3 as a conserved regulator of heart function.
Neely GG, Kuba K, Cammarato A, Isobe K, Amann S, Zhang L, Murata M, Elmén L, Gupta V, Arora S, Sarangi R, Dan D, Fujisawa S, Usami T, Xia CP, Keene AC, Alayari NN, Yamakawa H, Elling U, Berger C, Novatchkova M, Koglgruber R, Fukuda K, Nishina H, Isobe M, Pospisilik JA, Imai Y, Pfeufer A, Hicks AA, Pramstaller PP, Subramaniam S, Kimura A, Ocorr K, Bodmer R, Penninger JM. Neely GG, et al. Among authors: koglgruber r. Cell. 2010 Apr 2;141(1):142-53. doi: 10.1016/j.cell.2010.02.023. Cell. 2010. PMID: 20371351 Free PMC article.