Ruttekolk IR - Search Results

1

Cationic cell-penetrating peptides induce ceramide formation via acid sphingomyelinase: implications for uptake.

Verdurmen WP, Thanos M, Ruttekolk IR, Gulbins E, Brock R. Verdurmen WP, et al. Among authors: ruttekolk ir. J Control Release. 2010 Oct 15;147(2):171-9. doi: 10.1016/j.jconrel.2010.06.030. Epub 2010 Jul 8. J Control Release. 2010. PMID: 20620184

2

A cell-penetrating peptide derived from human lactoferrin with conformation-dependent uptake efficiency.

Duchardt F, Ruttekolk IR, Verdurmen WPR, Lortat-Jacob H, Bürck J, Hufnagel H, Fischer R, van den Heuvel M, Löwik DWPM, Vuister GW, Ulrich A, de Waard M, Brock R. Duchardt F, et al. Among authors: ruttekolk ir. J Biol Chem. 2009 Dec 25;284(52):36099-36108. doi: 10.1074/jbc.M109.036426. Epub 2009 Oct 26. J Biol Chem. 2009. PMID: 19858187 Free PMC article.

3

Measurements of the intracellular stability of CPPs.

Ruttekolk IR, Verdurmen WP, Chung YD, Brock R. Ruttekolk IR, et al. Methods Mol Biol. 2011;683:69-80. doi: 10.1007/978-1-60761-919-2_6. Methods Mol Biol. 2011. PMID: 21053123

4

HPMA as a scaffold for the modular assembly of functional peptide polymers by native chemical ligation.

Ruttekolk IR, Duchardt F, Fischer R, Wiesmüller KH, Rademann J, Brock R. Ruttekolk IR, et al. Bioconjug Chem. 2008 Oct;19(10):2081-7. doi: 10.1021/bc800222e. Epub 2008 Sep 9. Bioconjug Chem. 2008. PMID: 18778092

5

Coupling to polymeric scaffolds stabilizes biofunctional peptides for intracellular applications.

Ruttekolk IR, Chakrabarti A, Richter M, Duchardt F, Glauner H, Verdurmen WP, Rademann J, Brock R. Ruttekolk IR, et al. Mol Pharmacol. 2011 Apr;79(4):692-700. doi: 10.1124/mol.110.068296. Epub 2011 Jan 19. Mol Pharmacol. 2011. PMID: 21247935

6

The intracellular pharmacokinetics of terminally capped peptides.

Ruttekolk IR, Witsenburg JJ, Glauner H, Bovee-Geurts PH, Ferro ES, Verdurmen WP, Brock R. Ruttekolk IR, et al. Mol Pharm. 2012 May 7;9(5):1077-86. doi: 10.1021/mp200331g. Epub 2012 Apr 24. Mol Pharm. 2012. PMID: 22497602

7

Simultaneous detection of intracellular target and off-target binding of small molecule cancer drugs at nanomolar concentrations.

Glauner H, Ruttekolk IR, Hansen K, Steemers B, Chung YD, Becker F, Hannus S, Brock R. Glauner H, et al. Among authors: ruttekolk ir. Br J Pharmacol. 2010 Jun;160(4):958-70. doi: 10.1111/j.1476-5381.2010.00732.x. Br J Pharmacol. 2010. PMID: 20590591 Free PMC article.

8

A peptide-functionalized polymer as a minimal scaffold protein to enhance cluster formation in early T cell signal transduction.

Witsenburg JJ, Sinzinger MD, Stoevesandt O, Ruttekolk IR, Roth G, Adjobo-Hermans MJ, Brock R. Witsenburg JJ, et al. Among authors: ruttekolk ir. Chembiochem. 2015 Mar 2;16(4):602-10. doi: 10.1002/cbic.201402622. Epub 2015 Feb 6. Chembiochem. 2015. PMID: 25663649

9

Peptide microarrays to probe for competition for binding sites in a protein interaction network.

Sinzinger MD, Ruttekolk IR, Gloerich J, Wessels H, Chung YD, Adjobo-Hermans MJ, Brock R. Sinzinger MD, et al. Among authors: ruttekolk ir. J Proteomics. 2013 Aug 26;89:71-80. doi: 10.1016/j.jprot.2013.05.031. Epub 2013 Jun 5. J Proteomics. 2013. PMID: 23748025

10

Multivalent design of apoptosis-inducing bid-BH3 peptide-oligosaccharides boosts the intracellular activity at identical overall peptide concentrations.

Richter M, Chakrabarti A, Ruttekolk IR, Wiesner B, Beyermann M, Brock R, Rademann J. Richter M, et al. Among authors: ruttekolk ir. Chemistry. 2012 Dec 21;18(52):16708-15. doi: 10.1002/chem.201202276. Epub 2012 Nov 4. Chemistry. 2012. PMID: 23124530

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