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A WISP1 antibody inhibits MRTF signaling to prevent the progression of established liver fibrosis.
Xi Y, LaCanna R, Ma HY, N'Diaye EN, Gierke S, Caplazi P, Sagolla M, Huang Z, Lucio L, Arlantico A, Jeet S, Brightbill H, Emson C, Wong A, Morshead KB, DePianto DJ, Roose-Girma M, Yu C, Tam L, Jia G, Ramalingam TR, Marsters S, Ashkenazi A, Kim SH, Kelly R, Wu S, Wolters PJ, Feldstein AE, Vander Heiden JA, Ding N. Xi Y, et al. Among authors: lacanna r. Cell Metab. 2022 Sep 6;34(9):1377-1393.e8. doi: 10.1016/j.cmet.2022.07.009. Epub 2022 Aug 19. Cell Metab. 2022. PMID: 35987202 Free article.
Yap/Taz regulate alveolar regeneration and resolution of lung inflammation.
LaCanna R, Liccardo D, Zhang P, Tragesser L, Wang Y, Cao T, Chapman HA, Morrisey EE, Shen H, Koch WJ, Kosmider B, Wolfson MR, Tian Y. LaCanna R, et al. J Clin Invest. 2019 Apr 15;129(5):2107-2122. doi: 10.1172/JCI125014. eCollection 2019 Apr 15. J Clin Invest. 2019. PMID: 30985294 Free PMC article.
Extracellular BMP1 is the major proteinase for COOH-terminal proteolysis of type I procollagen in lung fibroblasts.
N'Diaye EN, Cook R, Wang H, Wu P, LaCanna R, Wu C, Ye Z, Seshasayee D, Hazen M, Lin W, Tyagi T, Hotzel I, Tam L, Newman R, Roose-Girma M, Wolters PJ, Ding N. N'Diaye EN, et al. Among authors: lacanna r. Am J Physiol Cell Physiol. 2021 Feb 1;320(2):C162-C174. doi: 10.1152/ajpcell.00012.2020. Epub 2020 Nov 18. Am J Physiol Cell Physiol. 2021. PMID: 33206546 Free article.
Class I Histone Deacetylase Inhibition for the Treatment of Sustained Atrial Fibrillation.
Seki M, LaCanna R, Powers JC, Vrakas C, Liu F, Berretta R, Chacko G, Holten J, Jadiya P, Wang T, Arkles JS, Copper JM, Houser SR, Huang J, Patel VV, Recchia FA. Seki M, et al. Among authors: lacanna r. J Pharmacol Exp Ther. 2016 Sep;358(3):441-9. doi: 10.1124/jpet.116.234591. Epub 2016 Jun 27. J Pharmacol Exp Ther. 2016. PMID: 27353074 Free PMC article.