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Year Number of Results
2013 1
2014 1
2015 4
2016 2
2017 5
2018 4
2019 7
2020 5
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2023 3
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33 results

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Page 1
[11C]MODAG-001-towards a PET tracer targeting α-synuclein aggregates.
Kuebler L, Buss S, Leonov A, Ryazanov S, Schmidt F, Maurer A, Weckbecker D, Landau AM, Lillethorup TP, Bleher D, Saw RS, Pichler BJ, Griesinger C, Giese A, Herfert K. Kuebler L, et al. Among authors: ryazanov s. Eur J Nucl Med Mol Imaging. 2021 Jun;48(6):1759-1772. doi: 10.1007/s00259-020-05133-x. Epub 2020 Dec 28. Eur J Nucl Med Mol Imaging. 2021. PMID: 33369690 Free PMC article.
Anle138b interaction in α-synuclein aggregates by dynamic nuclear polarization NMR.
Dervişoğlu R, Antonschmidt L, Nimerovsky E, Sant V, Kim M, Ryazanov S, Leonov A, Fuentes-Monteverde JC, Wegstroth M, Giller K, Mathies G, Giese A, Becker S, Griesinger C, Andreas LB. Dervişoğlu R, et al. Among authors: ryazanov s. Methods. 2023 Jun;214:18-27. doi: 10.1016/j.ymeth.2023.04.002. Epub 2023 Apr 8. Methods. 2023. PMID: 37037308 Free article.
Safety, tolerability and pharmacokinetics of the oligomer modulator anle138b with exposure levels sufficient for therapeutic efficacy in a murine Parkinson model: A randomised, double-blind, placebo-controlled phase 1a trial.
Levin J, Sing N, Melbourne S, Morgan A, Mariner C, Spillantini MG, Wegrzynowicz M, Dalley JW, Langer S, Ryazanov S, Leonov A, Griesinger C, Schmidt F, Weckbecker D, Prager K, Matthias T, Giese A. Levin J, et al. Among authors: ryazanov s. EBioMedicine. 2022 Jun;80:104021. doi: 10.1016/j.ebiom.2022.104021. Epub 2022 Apr 29. EBioMedicine. 2022. PMID: 35500536 Free PMC article. Clinical Trial.
Tau-induced mitochondrial membrane perturbation is dependent upon cardiolipin.
Camilleri A, Ghio S, Caruana M, Weckbecker D, Schmidt F, Kamp F, Leonov A, Ryazanov S, Griesinger C, Giese A, Cauchi RJ, Vassallo N. Camilleri A, et al. Among authors: ryazanov s. Biochim Biophys Acta Biomembr. 2020 Feb 1;1862(2):183064. doi: 10.1016/j.bbamem.2019.183064. Epub 2019 Sep 12. Biochim Biophys Acta Biomembr. 2020. PMID: 31521630 Free article.
The clinical drug candidate anle138b binds in a cavity of lipidic α-synuclein fibrils.
Antonschmidt L, Matthes D, Dervişoğlu R, Frieg B, Dienemann C, Leonov A, Nimerovsky E, Sant V, Ryazanov S, Giese A, Schröder GF, Becker S, de Groot BL, Griesinger C, Andreas LB. Antonschmidt L, et al. Among authors: ryazanov s. Nat Commun. 2022 Sep 14;13(1):5385. doi: 10.1038/s41467-022-32797-w. Nat Commun. 2022. PMID: 36104315 Free PMC article.
Photophysics of diphenyl-pyrazole compounds in solutions and α-synuclein aggregates.
Reiner AM, Schmidt F, Ryazanov S, Leonov A, Weckbecker D, Deeg AA, Griesinger C, Giese A, Zinth W. Reiner AM, et al. Among authors: ryazanov s. Biochim Biophys Acta Gen Subj. 2018 Apr;1862(4):800-807. doi: 10.1016/j.bbagen.2017.12.007. Epub 2017 Dec 19. Biochim Biophys Acta Gen Subj. 2018. PMID: 29273222
33 results