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A method for the generation of human stem cell-derived alpha cells.
Peterson QP, Veres A, Chen L, Slama MQ, Kenty JHR, Hassoun S, Brown MR, Dou H, Duffy CD, Zhou Q, Matveyenko AV, Tyrberg B, Sörhede-Winzell M, Rorsman P, Melton DA. Peterson QP, et al. Among authors: sorhede winzell m. Nat Commun. 2020 May 7;11(1):2241. doi: 10.1038/s41467-020-16049-3. Nat Commun. 2020. PMID: 32382023 Free PMC article.
Exploring the insulin secretory properties of the PGD2-GPR44/DP2 axis in vitro and in a randomized phase-1 trial of type 2 diabetes patients.
Skrtic S, Tyrberg B, Broberg M, Ericsson H, Schnecke V, Kjaer M, Hompesch M, Andersson EM, Ryberg E, Aivazidis A, Wennberg Huldt C, Löfgren L, Morrow L, Parkinson J, Rydén-Bergsten T, Watkins E, Sörhede Winzell M. Skrtic S, et al. Among authors: sorhede winzell m. PLoS One. 2018 Dec 17;13(12):e0208998. doi: 10.1371/journal.pone.0208998. eCollection 2018. PLoS One. 2018. PMID: 30557325 Free PMC article. Clinical Trial.
Secretagogin is increased in plasma from type 2 diabetes patients and potentially reflects stress and islet dysfunction.
Hansson SF, Zhou AX, Vachet P, Eriksson JW, Pereira MJ, Skrtic S, Jongsma Wallin H, Ericsson-Dahlstrand A, Karlsson D, Ahnmark A, Sörhede Winzell M, Magnone MC, Davidsson P. Hansson SF, et al. Among authors: sorhede winzell m. PLoS One. 2018 Apr 27;13(4):e0196601. doi: 10.1371/journal.pone.0196601. eCollection 2018. PLoS One. 2018. PMID: 29702679 Free PMC article.
CART is overexpressed in human type 2 diabetic islets and inhibits glucagon secretion and increases insulin secretion.
Abels M, Riva M, Bennet H, Ahlqvist E, Dyachok O, Nagaraj V, Shcherbina L, Fred RG, Poon W, Sörhede-Winzell M, Fadista J, Lindqvist A, Kask L, Sathanoori R, Dekker-Nitert M, Kuhar MJ, Ahrén B, Wollheim CB, Hansson O, Tengholm A, Fex M, Renström E, Groop L, Lyssenko V, Wierup N. Abels M, et al. Among authors: sorhede winzell m. Diabetologia. 2016 Sep;59(9):1928-37. doi: 10.1007/s00125-016-4020-6. Epub 2016 Jun 23. Diabetologia. 2016. PMID: 27338624
In Vivo Visualization of β-Cells by Targeting of GPR44.
Eriksson O, Johnström P, Cselenyi Z, Jahan M, Selvaraju RK, Jensen-Waern M, Takano A, Sörhede Winzell M, Halldin C, Skrtic S, Korsgren O. Eriksson O, et al. Among authors: sorhede winzell m. Diabetes. 2018 Feb;67(2):182-192. doi: 10.2337/db17-0764. Epub 2017 Dec 5. Diabetes. 2018. PMID: 29208633
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