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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1977 1
1978 1
1980 1
1981 2
1983 1
1984 2
1985 1
1986 1
1987 2
1988 3
1989 1
1992 1
1993 4
1994 6
1995 39
1996 54
1997 61
1998 85
1999 129
2000 130
2001 138
2002 157
2003 188
2004 212
2005 219
2006 284
2007 294
2008 288
2009 360
2010 345
2011 392
2012 475
2013 475
2014 504
2015 521
2016 488
2017 504
2018 561
2019 634
2020 621
2021 599
2022 555
2023 466
2024 173

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8,950 results

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The role of Smo-Shh/Gli signaling activation in the prevention of neurological and ageing disorders.
Prajapati A, Mehan S, Khan Z. Prajapati A, et al. Biogerontology. 2023 Aug;24(4):493-531. doi: 10.1007/s10522-023-10034-1. Epub 2023 Apr 25. Biogerontology. 2023. PMID: 37097427 Review.
Sonic hedgehog (Shh) signaling is an essential central nervous system (CNS) pathway involved during embryonic development and later life stages. ...Redox signalling has been found to play a critical role in regulating the activity of the Smo-Shh pathway and influenc …
Sonic hedgehog (Shh) signaling is an essential central nervous system (CNS) pathway involved during embryonic development and later l …
SHH inhibitors for the treatment of medulloblastoma.
Samkari A, White J, Packer R. Samkari A, et al. Expert Rev Neurother. 2015;15(7):763-70. doi: 10.1586/14737175.2015.1052796. Epub 2015 May 31. Expert Rev Neurother. 2015. PMID: 26027634 Review.
SHH inhibitors have become of great clinical interest in treating SHH-driven medulloblastoma. ...In this review, we present an overview of SHH medulloblastoma, as well as a discussion of currently available SHH inhibitors, and the challenges associated …
SHH inhibitors have become of great clinical interest in treating SHH-driven medulloblastoma. ...In this review, we present an …
The many lives of SHH in limb development and evolution.
Lopez-Rios J. Lopez-Rios J. Semin Cell Dev Biol. 2016 Jan;49:116-24. doi: 10.1016/j.semcdb.2015.12.018. Epub 2016 Jan 4. Semin Cell Dev Biol. 2016. PMID: 26762695 Review.
The SHH signaling pathway is essential for proper formation of the limb skeleton, as is required for the survival and expansion of distal chondrogenic progenitor cells. At the same time, SHH is important to specify digit identities along the anterior-posterior axis. …
The SHH signaling pathway is essential for proper formation of the limb skeleton, as is required for the survival and expansion of di …
Understanding Abnormal SMO-SHH Signaling in Autism Spectrum Disorder: Potential Drug Target and Therapeutic Goals.
Rahi S, Mehan S. Rahi S, et al. Cell Mol Neurobiol. 2022 May;42(4):931-953. doi: 10.1007/s10571-020-01010-1. Epub 2020 Nov 18. Cell Mol Neurobiol. 2022. PMID: 33206287 Review.
Dysregulation of SMO-SHH signaling leads to many physiological changes that lead to neurological disorders such as ASD and contribute to cognitive decline. ...We outlined in this review that SMO-SHH deregulation plays a crucial role in the pathogenesis of autism and …
Dysregulation of SMO-SHH signaling leads to many physiological changes that lead to neurological disorders such as ASD and contribute …
Sonic hedgehog (Shh) and CC chemokine ligand 2 signaling pathways in asthma.
Wang XZ, Zhang HH, Qian YL, Tang LF. Wang XZ, et al. J Chin Med Assoc. 2019 May;82(5):343-350. doi: 10.1097/JCMA.0000000000000094. J Chin Med Assoc. 2019. PMID: 31058710 Review.
Also, some signaling pathways are involved in the pathobiology of asthma. Sonic hedgehog (Shh) is one of the members of hedgehog gene families. Shh signaling plays a critical role in the embryonic development, including the lung. Previous findings from our team reve …
Also, some signaling pathways are involved in the pathobiology of asthma. Sonic hedgehog (Shh) is one of the members of hedgehog gene …
The role of Shh signalling pathway in central nervous system development and related diseases.
Li X, Li Y, Li S, Li H, Yang C, Lin J. Li X, et al. Cell Biochem Funct. 2021 Mar;39(2):180-189. doi: 10.1002/cbf.3582. Epub 2020 Aug 25. Cell Biochem Funct. 2021. PMID: 32840890 Review.
The abnormal signalling pathway of Shh leads to the occurrence of many nervous system diseases. The mechanism of Shh signalling is complex and remains incompletely understood. ...It also presented the author's opinions on the future research direction of Shh …
The abnormal signalling pathway of Shh leads to the occurrence of many nervous system diseases. The mechanism of Shh signallin …
SHH pathway inhibition is protumourigenic in adamantinomatous craniopharyngioma.
Carreno G, Boult JKR, Apps J, Gonzalez-Meljem JM, Haston S, Guiho R, Stache C, Danielson LS, Koers A, Smith LM, Virasami A, Panousopoulos L, Buchfelder M, Jacques TS, Chesler L, Robinson SP, Martinez-Barbera JP. Carreno G, et al. Endocr Relat Cancer. 2019 Mar;26(3):355-366. doi: 10.1530/ERC-18-0538. Endocr Relat Cancer. 2019. PMID: 30645190 Free PMC article.
Pharmacological inhibition of the sonic hedgehog (SHH) pathway can be beneficial against certain cancers but detrimental in others. ...Together, our results demonstrate a protumourigenic effect of vismodegib-mediated SHH pathway inhibition in ACP....
Pharmacological inhibition of the sonic hedgehog (SHH) pathway can be beneficial against certain cancers but detrimental in others. . …
ATRT-SHH comprises three molecular subgroups with characteristic clinical and histopathological features and prognostic significance.
Federico A, Thomas C, Miskiewicz K, Woltering N, Zin F, Nemes K, Bison B, Johann PD, Hawes D, Bens S, Kordes U, Albrecht S, Dohmen H, Hauser P, Keyvani K, van Landeghem FKH, Lund EL, Scheie D, Mawrin C, Monoranu CM, Parm Ulhøi B, Pietsch T, Reinhard H, Riemenschneider MJ, Sehested A, Sumerauer D, Siebert R, Paulus W, Frühwald MC, Kool M, Hasselblatt M. Federico A, et al. Acta Neuropathol. 2022 Jun;143(6):697-711. doi: 10.1007/s00401-022-02424-5. Epub 2022 Apr 30. Acta Neuropathol. 2022. PMID: 35501487 Free PMC article.
We, therefore, aimed to investigate if heterogeneity within ATRT-SHH might also have biological and clinical importance. Consensus clustering of DNA methylation profiles and confirmatory t-SNE analysis of 65 ATRT-SHH yielded three robust molecular subgroups, i.e., …
We, therefore, aimed to investigate if heterogeneity within ATRT-SHH might also have biological and clinical importance. Consensus cl …
Moving the Shh Source over Time: What Impact on Neural Cell Diversification in the Developing Spinal Cord?
Danesin C, Soula C. Danesin C, et al. J Dev Biol. 2017 Apr 12;5(2):4. doi: 10.3390/jdb5020004. J Dev Biol. 2017. PMID: 29615562 Free PMC article. Review.
Although less studied, the identity and position of Shh source cells also undergo significant changes over time, raising the question of how moving the Shh source contributes to cell diversification in response to the morphogen. Here, we focus on the dynamics of …
Although less studied, the identity and position of Shh source cells also undergo significant changes over time, raising the question …
Protein arginine methyltransferase 5 regulates SHH-subgroup medulloblastoma progression.
Wynn DT, Rodriguez-Blanco J, Long J, Yang F, Shen C, Fei D, Tang HY, Hanson D, Robbins DJ. Wynn DT, et al. Neurooncol Adv. 2022 Sep 29;4(1):vdac144. doi: 10.1093/noajnl/vdac144. eCollection 2022 Jan-Dec. Neurooncol Adv. 2022. PMID: 36299796 Free PMC article.
RESULTS: PRMT5 is overexpressed in SHH-MB tissue. Furthermore, SHH-MB viability and SHH activity is dependent on PRMT5. We found that GLI1 isolated from SHH-MB tissues is highly methylated, including three PRMT5 sites that affect SHH-MB cell via …
RESULTS: PRMT5 is overexpressed in SHH-MB tissue. Furthermore, SHH-MB viability and SHH activity is dependent on PRMT5. …
8,950 results