Sacchettini JC - Search Results

1

The Tuberculosis Drug Accelerator at year 10: what have we learned?

Aldridge BB, Barros-Aguirre D, Barry CE 3rd, Bates RH, Berthel SJ, Boshoff HI, Chibale K, Chu XJ, Cooper CB, Dartois V, Duncan K, Fotouhi N, Gusovsky F, Hipskind PA, Kempf DJ, Lelièvre J, Lenaerts AJ, McNamara CW, Mizrahi V, Nathan C, Olsen DB, Parish T, Petrassi HM, Pym A, Rhee KY, Robertson GT, Rock JM, Rubin EJ, Russell B, Russell DG, Sacchettini JC, Schnappinger D, Schrimpf M, Upton AM, Warner P, Wyatt PG, Yuan Y. Aldridge BB, et al. Among authors: sacchettini jc. Nat Med. 2021 Aug;27(8):1333-1337. doi: 10.1038/s41591-021-01442-2. Nat Med. 2021. PMID: 34226736 Free PMC article.

2

Rational design of potent human transthyretin amyloid disease inhibitors.

Klabunde T, Petrassi HM, Oza VB, Raman P, Kelly JW, Sacchettini JC. Klabunde T, et al. Among authors: sacchettini jc. Nat Struct Biol. 2000 Apr;7(4):312-21. doi: 10.1038/74082. Nat Struct Biol. 2000. PMID: 10742177

3

Structure of isocitrate lyase, a persistence factor of Mycobacterium tuberculosis.

Sharma V, Sharma S, Hoener zu Bentrup K, McKinney JD, Russell DG, Jacobs WR Jr, Sacchettini JC. Sharma V, et al. Among authors: sacchettini jc. Nat Struct Biol. 2000 Aug;7(8):663-8. doi: 10.1038/77964. Nat Struct Biol. 2000. PMID: 10932251

4

Persistence of Mycobacterium tuberculosis in macrophages and mice requires the glyoxylate shunt enzyme isocitrate lyase.

McKinney JD, Höner zu Bentrup K, Muñoz-Elías EJ, Miczak A, Chen B, Chan WT, Swenson D, Sacchettini JC, Jacobs WR Jr, Russell DG. McKinney JD, et al. Among authors: sacchettini jc. Nature. 2000 Aug 17;406(6797):735-8. doi: 10.1038/35021074. Nature. 2000. PMID: 10963599

5

An engineered transthyretin monomer that is nonamyloidogenic, unless it is partially denatured.

Jiang X, Smith CS, Petrassi HM, Hammarström P, White JT, Sacchettini JC, Kelly JW. Jiang X, et al. Among authors: sacchettini jc. Biochemistry. 2001 Sep 25;40(38):11442-52. doi: 10.1021/bi011194d. Biochemistry. 2001. PMID: 11560492

6

Biochemical and structural studies of malate synthase from Mycobacterium tuberculosis.

Smith CV, Huang CC, Miczak A, Russell DG, Sacchettini JC, Höner zu Bentrup K. Smith CV, et al. Among authors: sacchettini jc. J Biol Chem. 2003 Jan 17;278(3):1735-43. doi: 10.1074/jbc.M209248200. Epub 2002 Oct 21. J Biol Chem. 2003. PMID: 12393860 Free article.

7

Bisaryloxime ethers as potent inhibitors of transthyretin amyloid fibril formation.

Johnson SM, Petrassi HM, Palaninathan SK, Mohamedmohaideen NN, Purkey HE, Nichols C, Chiang KP, Walkup T, Sacchettini JC, Sharpless KB, Kelly JW. Johnson SM, et al. Among authors: sacchettini jc. J Med Chem. 2005 Mar 10;48(5):1576-87. doi: 10.1021/jm049274d. J Med Chem. 2005. PMID: 15743199

8

M. tuberculosis Rv2252 encodes a diacylglycerol kinase involved in the biosynthesis of phosphatidylinositol mannosides (PIMs).

Owens RM, Hsu FF, VanderVen BC, Purdy GE, Hesteande E, Giannakas P, Sacchettini JC, McKinney JD, Hill PJ, Belisle JT, Butcher BA, Pethe K, Russell DG. Owens RM, et al. Among authors: sacchettini jc. Mol Microbiol. 2006 Jun;60(5):1152-63. doi: 10.1111/j.1365-2958.2006.05174.x. Mol Microbiol. 2006. PMID: 16689792 Free article.

9

Mechanism of thioamide drug action against tuberculosis and leprosy.

Wang F, Langley R, Gulten G, Dover LG, Besra GS, Jacobs WR Jr, Sacchettini JC. Wang F, et al. Among authors: sacchettini jc. J Exp Med. 2007 Jan 22;204(1):73-8. doi: 10.1084/jem.20062100. Epub 2007 Jan 16. J Exp Med. 2007. PMID: 17227913 Free PMC article.

10

Drugs versus bugs: in pursuit of the persistent predator Mycobacterium tuberculosis.

Sacchettini JC, Rubin EJ, Freundlich JS. Sacchettini JC, et al. Nat Rev Microbiol. 2008 Jan;6(1):41-52. doi: 10.1038/nrmicro1816. Nat Rev Microbiol. 2008. PMID: 18079742 Review.

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