Saftig P - Search Results

1

Targeting cardiomyocyte ADAM10 ectodomain shedding promotes survival early after myocardial infarction.

Klapproth E, Witt A, Klose P, Wiedemann J, Vavilthota N, Künzel SR, Kämmerer S, Günscht M, Sprott D, Lesche M, Rost F, Dahl A, Rauch E, Kattner L, Weber S, Mirtschink P, Kopaliani I, Guan K, Lorenz K, Saftig P, Wagner M, El-Armouche A. Klapproth E, et al. Among authors: saftig p. Nat Commun. 2022 Dec 10;13(1):7648. doi: 10.1038/s41467-022-35331-0. Nat Commun. 2022. PMID: 36496449 Free PMC article.

2

The disintegrin-like metalloproteinase ADAM10 is involved in constitutive cleavage of CX3CL1 (fractalkine) and regulates CX3CL1-mediated cell-cell adhesion.

Hundhausen C, Misztela D, Berkhout TA, Broadway N, Saftig P, Reiss K, Hartmann D, Fahrenholz F, Postina R, Matthews V, Kallen KJ, Rose-John S, Ludwig A. Hundhausen C, et al. Among authors: saftig p. Blood. 2003 Aug 15;102(4):1186-95. doi: 10.1182/blood-2002-12-3775. Epub 2003 Apr 24. Blood. 2003. PMID: 12714508 Free article.

3

Cellular cholesterol depletion triggers shedding of the human interleukin-6 receptor by ADAM10 and ADAM17 (TACE).

Matthews V, Schuster B, Schütze S, Bussmeyer I, Ludwig A, Hundhausen C, Sadowski T, Saftig P, Hartmann D, Kallen KJ, Rose-John S. Matthews V, et al. Among authors: saftig p. J Biol Chem. 2003 Oct 3;278(40):38829-39. doi: 10.1074/jbc.M210584200. Epub 2003 Jun 27. J Biol Chem. 2003. PMID: 12832423 Free article.

4

The transmembrane CXC-chemokine ligand 16 is induced by IFN-gamma and TNF-alpha and shed by the activity of the disintegrin-like metalloproteinase ADAM10.

Abel S, Hundhausen C, Mentlein R, Schulte A, Berkhout TA, Broadway N, Hartmann D, Sedlacek R, Dietrich S, Muetze B, Schuster B, Kallen KJ, Saftig P, Rose-John S, Ludwig A. Abel S, et al. Among authors: saftig p. J Immunol. 2004 May 15;172(10):6362-72. doi: 10.4049/jimmunol.172.10.6362. J Immunol. 2004. PMID: 15128827

5

ADAM10 cleavage of N-cadherin and regulation of cell-cell adhesion and beta-catenin nuclear signalling.

Reiss K, Maretzky T, Ludwig A, Tousseyn T, de Strooper B, Hartmann D, Saftig P. Reiss K, et al. Among authors: saftig p. EMBO J. 2005 Feb 23;24(4):742-52. doi: 10.1038/sj.emboj.7600548. Epub 2005 Feb 3. EMBO J. 2005. PMID: 15692570 Free PMC article.

6

ADAM10 mediates E-cadherin shedding and regulates epithelial cell-cell adhesion, migration, and beta-catenin translocation.

Maretzky T, Reiss K, Ludwig A, Buchholz J, Scholz F, Proksch E, de Strooper B, Hartmann D, Saftig P. Maretzky T, et al. Among authors: saftig p. Proc Natl Acad Sci U S A. 2005 Jun 28;102(26):9182-7. doi: 10.1073/pnas.0500918102. Epub 2005 Jun 15. Proc Natl Acad Sci U S A. 2005. PMID: 15958533 Free PMC article.

7

L1 is sequentially processed by two differently activated metalloproteases and presenilin/gamma-secretase and regulates neural cell adhesion, cell migration, and neurite outgrowth.

Maretzky T, Schulte M, Ludwig A, Rose-John S, Blobel C, Hartmann D, Altevogt P, Saftig P, Reiss K. Maretzky T, et al. Among authors: saftig p. Mol Cell Biol. 2005 Oct;25(20):9040-53. doi: 10.1128/MCB.25.20.9040-9053.2005. Mol Cell Biol. 2005. PMID: 16199880 Free PMC article.

8

Regulated ADAM10-dependent ectodomain shedding of gamma-protocadherin C3 modulates cell-cell adhesion.

Reiss K, Maretzky T, Haas IG, Schulte M, Ludwig A, Frank M, Saftig P. Reiss K, et al. Among authors: saftig p. J Biol Chem. 2006 Aug 4;281(31):21735-21744. doi: 10.1074/jbc.M602663200. Epub 2006 Jun 2. J Biol Chem. 2006. PMID: 16751190 Free article.

9

ADAM10 regulates FasL cell surface expression and modulates FasL-induced cytotoxicity and activation-induced cell death.

Schulte M, Reiss K, Lettau M, Maretzky T, Ludwig A, Hartmann D, de Strooper B, Janssen O, Saftig P. Schulte M, et al. Among authors: saftig p. Cell Death Differ. 2007 May;14(5):1040-9. doi: 10.1038/sj.cdd.4402101. Epub 2007 Feb 9. Cell Death Differ. 2007. PMID: 17290285

10

Regulated shedding of transmembrane chemokines by the disintegrin and metalloproteinase 10 facilitates detachment of adherent leukocytes.

Hundhausen C, Schulte A, Schulz B, Andrzejewski MG, Schwarz N, von Hundelshausen P, Winter U, Paliga K, Reiss K, Saftig P, Weber C, Ludwig A. Hundhausen C, et al. Among authors: saftig p. J Immunol. 2007 Jun 15;178(12):8064-72. doi: 10.4049/jimmunol.178.12.8064. J Immunol. 2007. PMID: 17548644

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