Sajan MP - Search Results

1

Deletion of Protein Kinase C λ in POMC Neurons Predisposes to Diet-Induced Obesity.

Dorfman MD, Krull JE, Scarlett JM, Guyenet SJ, Sajan MP, Damian V, Nguyen HT, Leitges M, Morton GJ, Farese RV, Schwartz MW, Thaler JP. Dorfman MD, et al. Among authors: sajan mp. Diabetes. 2017 Apr;66(4):920-934. doi: 10.2337/db16-0482. Epub 2017 Jan 10. Diabetes. 2017. PMID: 28073831 Free PMC article.

2

Brain Insulin Signaling Is Increased in Insulin-Resistant States and Decreases in FOXOs and PGC-1α and Increases in Aβ1-40/42 and Phospho-Tau May Abet Alzheimer Development.

Sajan M, Hansen B, Ivey R 3rd, Sajan J, Ari C, Song S, Braun U, Leitges M, Farese-Higgs M, Farese RV. Sajan M, et al. Diabetes. 2016 Jul;65(7):1892-903. doi: 10.2337/db15-1428. Epub 2016 Feb 19. Diabetes. 2016. PMID: 26895791 Free PMC article.

3

Skeletal muscle insulin resistance in obesity-associated type 2 diabetes in monkeys is linked to a defect in insulin activation of protein kinase C-zeta/lambda/iota.

Standaert ML, Ortmeyer HK, Sajan MP, Kanoh Y, Bandyopadhyay G, Hansen BC, Farese RV. Standaert ML, et al. Among authors: sajan mp. Diabetes. 2002 Oct;51(10):2936-43. doi: 10.2337/diabetes.51.10.2936. Diabetes. 2002. PMID: 12351430

4

Activation of protein kinase C-zeta by insulin and phosphatidylinositol-3,4,5-(PO4)3 is defective in muscle in type 2 diabetes and impaired glucose tolerance: amelioration by rosiglitazone and exercise.

Beeson M, Sajan MP, Dizon M, Grebenev D, Gomez-Daspet J, Miura A, Kanoh Y, Powe J, Bandyopadhyay G, Standaert ML, Farese RV. Beeson M, et al. Among authors: sajan mp. Diabetes. 2003 Aug;52(8):1926-34. doi: 10.2337/diabetes.52.8.1926. Diabetes. 2003. PMID: 12882907 Clinical Trial.

5

Insulin-sensitive protein kinases (atypical protein kinase C and protein kinase B/Akt): actions and defects in obesity and type II diabetes.

Farese RV, Sajan MP, Standaert ML. Farese RV, et al. Among authors: sajan mp. Exp Biol Med (Maywood). 2005 Oct;230(9):593-605. doi: 10.1177/153537020523000901. Exp Biol Med (Maywood). 2005. PMID: 16179727 Review.

6

Atypical protein kinase C activity in the hypothalamus is required for lipopolysaccharide-mediated sickness responses.

Thaler JP, Choi SJ, Sajan MP, Ogimoto K, Nguyen HT, Matsen M, Benoit SC, Wisse BE, Farese RV, Schwartz MW. Thaler JP, et al. Among authors: sajan mp. Endocrinology. 2009 Dec;150(12):5362-72. doi: 10.1210/en.2009-0509. Epub 2009 Oct 9. Endocrinology. 2009. PMID: 19819945 Free PMC article.

7

Metabolic functions of atypical protein kinase C: "good" and "bad" as defined by nutritional status.

Farese RV, Sajan MP. Farese RV, et al. Among authors: sajan mp. Am J Physiol Endocrinol Metab. 2010 Mar;298(3):E385-94. doi: 10.1152/ajpendo.00608.2009. Epub 2009 Dec 8. Am J Physiol Endocrinol Metab. 2010. PMID: 19996389 Free PMC article. Review.

8

Atypical protein kinase C in cardiometabolic abnormalities.

Farese RV, Sajan MP. Farese RV, et al. Among authors: sajan mp. Curr Opin Lipidol. 2012 Jun;23(3):175-181. doi: 10.1097/MOL.0b013e328352c4c7. Curr Opin Lipidol. 2012. PMID: 22449812 Free PMC article. Review.

9

Akt-dependent phosphorylation of hepatic FoxO1 is compartmentalized on a WD40/ProF scaffold and is selectively inhibited by aPKC in early phases of diet-induced obesity.

Sajan MP, Acevedo-Duncan ME, Standaert ML, Ivey RA, Lee M, Farese RV. Sajan MP, et al. Diabetes. 2014 Aug;63(8):2690-701. doi: 10.2337/db13-1863. Epub 2014 Apr 4. Diabetes. 2014. PMID: 24705403 Free PMC article.

10

Defective activation of atypical protein kinase C zeta and lambda by insulin and phosphatidylinositol-3,4,5-(PO4)(3) in skeletal muscle of rats following high-fat feeding and streptozotocin-induced diabetes.

Kanoh Y, Sajan MP, Bandyopadhyay G, Miura A, Standaert ML, Farese RV. Kanoh Y, et al. Among authors: sajan mp. Endocrinology. 2003 Mar;144(3):947-54. doi: 10.1210/en.2002-221017. Endocrinology. 2003. PMID: 12586772

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