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Design, synthesis, and biological evaluation of novel matrix metalloproteinase inhibitors as potent antihemorrhagic agents: from hit identification to an optimized lead.
J Med Chem. 2015 Mar 12;58(5):2465-88. doi: 10.1021/jm501940y. Epub 2015 Feb 25.
J Med Chem. 2015.
PMID: 25686153
Discovery and safety profiling of a potent preclinical candidate, (4-[4-[[(3R)-3-(hydroxycarbamoyl)-8-azaspiro[4.5]decan-3-yl]sulfonyl]phenoxy]-N-methylbenzamide) (CM-352), for the prevention and treatment of hemorrhage.
Orbe J, Rodríguez JA, Sánchez-Arias JA, Salicio A, Belzunce M, Ugarte A, Chang HC, Rabal O, Oyarzabal J, Páramo JA.
Orbe J, et al. Among authors: salicio a.
J Med Chem. 2015 Apr 9;58(7):2941-57. doi: 10.1021/jm501939z. Epub 2015 Feb 25.
J Med Chem. 2015.
PMID: 25686022
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Phenotypic Screening To Discover Novel Chemical Series as Efficient Antihemorrhagic Agents.
de Miguel I, Orbe J, Sánchez-Arias JA, Rodríguez JA, Salicio A, Rabal O, Belzunce M, Sáez E, Xu M, Wu W, Tan H, Ma H, Páramo JA, Oyarzabal J.
de Miguel I, et al. Among authors: salicio a.
ACS Med Chem Lett. 2018 Apr 16;9(5):428-433. doi: 10.1021/acsmedchemlett.7b00549. eCollection 2018 May 10.
ACS Med Chem Lett. 2018.
PMID: 29795754
Free PMC article.
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New thrombolytic strategy providing neuroprotection in experimental ischemic stroke: MMP10 alone or in combination with tissue-type plasminogen activator.
Roncal C, Martinez de Lizarrondo S, Salicio A, Chevilley A, Rodriguez JA, Rosell A, Couraud PO, Weksler B, Montaner J, Vivien D, Páramo JA, Orbe J.
Roncal C, et al. Among authors: salicio a.
Cardiovasc Res. 2017 Aug 1;113(10):1219-1229. doi: 10.1093/cvr/cvx069.
Cardiovasc Res. 2017.
PMID: 28379489
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MMP10 Promotes Efficient Thrombolysis After Ischemic Stroke in Mice with Induced Diabetes.
Navarro-Oviedo M, Roncal C, Salicio A, Belzunce M, Rabal O, Toledo E, Zandio B, Rodríguez JA, Páramo JA, Muñoz R, Orbe J.
Navarro-Oviedo M, et al. Among authors: salicio a.
Transl Stroke Res. 2019 Aug;10(4):389-401. doi: 10.1007/s12975-018-0652-9. Epub 2018 Jul 27.
Transl Stroke Res. 2019.
PMID: 30051168
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Activated protein C β-glycoform promotes enhanced noncanonical PAR1 proteolysis and superior resistance to ischemic injury.
Gleeson EM, Dichiara MG, Salicio A, Quinn LM, Drakeford C, Russell SE, Walsh PT, Orbe J, Hermida J, Smith OP, O'Donnell JS, Montes R, Preston RJ.
Gleeson EM, et al. Among authors: salicio a.
Blood. 2015 Aug 13;126(7):915-9. doi: 10.1182/blood-2015-03-632877. Epub 2015 Jun 17.
Blood. 2015.
PMID: 26084674
Free article.
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