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Page 1
Viral MLKL Homologs Subvert Necroptotic Cell Death by Sequestering Cellular RIPK3.
Petrie EJ, Sandow JJ, Lehmann WIL, Liang LY, Coursier D, Young SN, Kersten WJA, Fitzgibbon C, Samson AL, Jacobsen AV, Lowes KN, Au AE, Jousset Sabroux H, Lalaoui N, Webb AI, Lessene G, Manning G, Lucet IS, Murphy JM. Petrie EJ, et al. Among authors: samson al. Cell Rep. 2019 Sep 24;28(13):3309-3319.e5. doi: 10.1016/j.celrep.2019.08.055. Cell Rep. 2019. PMID: 31553902 Free article.
Necroptosis is dispensable for motor neuron degeneration in a mouse model of ALS.
Wang T, Perera ND, Chiam MDF, Cuic B, Wanniarachchillage N, Tomas D, Samson AL, Cawthorne W, Valor EN, Murphy JM, Turner BJ. Wang T, et al. Among authors: samson al. Cell Death Differ. 2020 May;27(5):1728-1739. doi: 10.1038/s41418-019-0457-8. Epub 2019 Nov 19. Cell Death Differ. 2020. PMID: 31745214 Free PMC article.
Identification of MLKL membrane translocation as a checkpoint in necroptotic cell death using Monobodies.
Petrie EJ, Birkinshaw RW, Koide A, Denbaum E, Hildebrand JM, Garnish SE, Davies KA, Sandow JJ, Samson AL, Gavin X, Fitzgibbon C, Young SN, Hennessy PJ, Smith PPC, Webb AI, Czabotar PE, Koide S, Murphy JM. Petrie EJ, et al. Among authors: samson al. Proc Natl Acad Sci U S A. 2020 Apr 14;117(15):8468-8475. doi: 10.1073/pnas.1919960117. Epub 2020 Mar 31. Proc Natl Acad Sci U S A. 2020. PMID: 32234780 Free PMC article.
MLKL trafficking and accumulation at the plasma membrane control the kinetics and threshold for necroptosis.
Samson AL, Zhang Y, Geoghegan ND, Gavin XJ, Davies KA, Mlodzianoski MJ, Whitehead LW, Frank D, Garnish SE, Fitzgibbon C, Hempel A, Young SN, Jacobsen AV, Cawthorne W, Petrie EJ, Faux MC, Shield-Artin K, Lalaoui N, Hildebrand JM, Silke J, Rogers KL, Lessene G, Hawkins ED, Murphy JM. Samson AL, et al. Nat Commun. 2020 Jun 19;11(1):3151. doi: 10.1038/s41467-020-16887-1. Nat Commun. 2020. PMID: 32561730 Free PMC article.
A toolbox for imaging RIPK1, RIPK3, and MLKL in mouse and human cells.
Samson AL, Fitzgibbon C, Patel KM, Hildebrand JM, Whitehead LW, Rimes JS, Jacobsen AV, Horne CR, Gavin XJ, Young SN, Rogers KL, Hawkins ED, Murphy JM. Samson AL, et al. Cell Death Differ. 2021 Jul;28(7):2126-2144. doi: 10.1038/s41418-021-00742-x. Epub 2021 Feb 15. Cell Death Differ. 2021. PMID: 33589776 Free PMC article.
Conformational interconversion of MLKL and disengagement from RIPK3 precede cell death by necroptosis.
Garnish SE, Meng Y, Koide A, Sandow JJ, Denbaum E, Jacobsen AV, Yeung W, Samson AL, Horne CR, Fitzgibbon C, Young SN, Smith PPC, Webb AI, Petrie EJ, Hildebrand JM, Kannan N, Czabotar PE, Koide S, Murphy JM. Garnish SE, et al. Among authors: samson al. Nat Commun. 2021 Apr 13;12(1):2211. doi: 10.1038/s41467-021-22400-z. Nat Commun. 2021. PMID: 33850121 Free PMC article.
Ferroptosis mediates selective motor neuron death in amyotrophic lateral sclerosis.
Wang T, Tomas D, Perera ND, Cuic B, Luikinga S, Viden A, Barton SK, McLean CA, Samson AL, Southon A, Bush AI, Murphy JM, Turner BJ. Wang T, et al. Among authors: samson al. Cell Death Differ. 2022 Jun;29(6):1187-1198. doi: 10.1038/s41418-021-00910-z. Epub 2021 Dec 2. Cell Death Differ. 2022. PMID: 34857917 Free PMC article.
54 results