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Rational optimization of a transcription factor activation domain inhibitor.
Nat Struct Mol Biol. 2023 Dec;30(12):1958-1969. doi: 10.1038/s41594-023-01159-5. Epub 2023 Dec 4.
Nat Struct Mol Biol. 2023.
PMID: 38049566
Free PMC article.
Discovery and Mechanistic Elucidation of NQO1-Bioactivatable Small Molecules That Overcome Resistance to Degraders.
Barbosa BMG, Sfyaki A, Rafael S, José-Duran F, Pous J, Sánchez-Zarzalejo C, Perez-Lopez C, Vilanova M, Cigler M, Gay M, Vilaseca M, Winter GE, Riera A, Mayor-Ruiz C.
Barbosa BMG, et al. Among authors: sanchez zarzalejo c.
Angew Chem Int Ed Engl. 2024 Mar 18;63(12):e202316730. doi: 10.1002/anie.202316730. Epub 2024 Jan 18.
Angew Chem Int Ed Engl. 2024.
PMID: 38153885
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Optimal linker length for small molecule PROTACs that selectively target p38α and p38β for degradation.
Donoghue C, Cubillos-Rojas M, Gutierrez-Prat N, Sanchez-Zarzalejo C, Verdaguer X, Riera A, Nebreda AR.
Donoghue C, et al. Among authors: sanchez zarzalejo c.
Eur J Med Chem. 2020 Sep 1;201:112451. doi: 10.1016/j.ejmech.2020.112451. Epub 2020 Jun 18.
Eur J Med Chem. 2020.
PMID: 32634680
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