Santell L - Search Results

1

Conformational lability in serine protease active sites: structures of hepatocyte growth factor activator (HGFA) alone and with the inhibitory domain from HGFA inhibitor-1B.

Shia S, Stamos J, Kirchhofer D, Fan B, Wu J, Corpuz RT, Santell L, Lazarus RA, Eigenbrot C. Shia S, et al. Among authors: santell l. J Mol Biol. 2005 Mar 11;346(5):1335-49. doi: 10.1016/j.jmb.2004.12.048. Epub 2005 Jan 28. J Mol Biol. 2005. PMID: 15713485

2

Structural and functional basis of the serine protease-like hepatocyte growth factor beta-chain in Met binding and signaling.

Kirchhofer D, Yao X, Peek M, Eigenbrot C, Lipari MT, Billeci KL, Maun HR, Moran P, Santell L, Wiesmann C, Lazarus RA. Kirchhofer D, et al. Among authors: santell l. J Biol Chem. 2004 Sep 17;279(38):39915-24. doi: 10.1074/jbc.M404795200. Epub 2004 Jun 24. J Biol Chem. 2004. PMID: 15218027 Free article.

3

Utilizing the activation mechanism of serine proteases to engineer hepatocyte growth factor into a Met antagonist.

Kirchhofer D, Lipari MT, Santell L, Billeci KL, Maun HR, Sandoval WN, Moran P, Ridgway J, Eigenbrot C, Lazarus RA. Kirchhofer D, et al. Among authors: santell l. Proc Natl Acad Sci U S A. 2007 Mar 27;104(13):5306-11. doi: 10.1073/pnas.0700184104. Epub 2007 Mar 19. Proc Natl Acad Sci U S A. 2007. PMID: 17372204 Free PMC article.

4

Noncompetitive inhibition of hepatocyte growth factor-dependent Met signaling by a phage-derived peptide.

Tam EM, Runyon ST, Santell L, Quan C, Yao X, Kirchhofer D, Skelton NJ, Lazarus RA. Tam EM, et al. Among authors: santell l. J Mol Biol. 2009 Jan 9;385(1):79-90. doi: 10.1016/j.jmb.2008.09.091. Epub 2008 Oct 15. J Mol Biol. 2009. PMID: 18973760

5

The factor VII zymogen structure reveals reregistration of beta strands during activation.

Eigenbrot C, Kirchhofer D, Dennis MS, Santell L, Lazarus RA, Stamos J, Ultsch MH. Eigenbrot C, et al. Among authors: santell l. Structure. 2001 Jul 3;9(7):627-36. doi: 10.1016/s0969-2126(01)00624-4. Structure. 2001. PMID: 11470437 Free article.

6

Allosteric peptide activators of pro-hepatocyte growth factor stimulate Met signaling.

Landgraf KE, Santell L, Billeci KL, Quan C, Young JC, Maun HR, Kirchhofer D, Lazarus RA. Landgraf KE, et al. Among authors: santell l. J Biol Chem. 2010 Dec 17;285(51):40362-72. doi: 10.1074/jbc.M110.179721. Epub 2010 Oct 11. J Biol Chem. 2010. PMID: 20937841 Free PMC article.

7

Proteolytic activation of pro-macrophage-stimulating protein by hepsin.

Ganesan R, Kolumam GA, Lin SJ, Xie MH, Santell L, Wu TD, Lazarus RA, Chaudhuri A, Kirchhofer D. Ganesan R, et al. Among authors: santell l. Mol Cancer Res. 2011 Sep;9(9):1175-86. doi: 10.1158/1541-7786.MCR-11-0004. Epub 2011 Aug 29. Mol Cancer Res. 2011. PMID: 21875933

8

An allosteric switch for pro-HGF/Met signaling using zymogen activator peptides.

Landgraf KE, Steffek M, Quan C, Tom J, Yu C, Santell L, Maun HR, Eigenbrot C, Lazarus RA. Landgraf KE, et al. Among authors: santell l. Nat Chem Biol. 2014 Jul;10(7):567-73. doi: 10.1038/nchembio.1533. Epub 2014 May 25. Nat Chem Biol. 2014. PMID: 24859116

9

Peptide exosite inhibitors of factor VIIa as anticoagulants.

Dennis MS, Eigenbrot C, Skelton NJ, Ultsch MH, Santell L, Dwyer MA, O'Connell MP, Lazarus RA. Dennis MS, et al. Among authors: santell l. Nature. 2000 Mar 30;404(6777):465-70. doi: 10.1038/35006574. Nature. 2000. PMID: 10761907

10

A novel exosite on coagulation factor VIIa and its molecular interactions with a new class of peptide inhibitors.

Roberge M, Santell L, Dennis MS, Eigenbrot C, Dwyer MA, Lazarus RA. Roberge M, et al. Among authors: santell l. Biochemistry. 2001 Aug 14;40(32):9522-31. doi: 10.1021/bi010592d. Biochemistry. 2001. PMID: 11583151

A. (2001) Biochemistry 40, 9513-9521], specifically bind at a site that is distinct from both the active site and the exosite of another recently described peptide inhibitor of FVIIa, E-76 [Dennis, M. S., Eigenbrot, C., Skelton, N. J., Ultsch, M. H., Santell, L., Dw …

A. (2001) Biochemistry 40, 9513-9521], specifically bind at a site that is distinct from both the active site and the exosite of another rec …

Save citations to file

Email citations

Send citations to clipboard

Add to Collections

Add to My Bibliography

Create a file for external citation management software

Your saved search

Your RSS Feed

My NCBI Filters

Text availability

Article attribute

Article type

Publication date

30 results

Search Page