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Hepcidin is regulated by promoter-associated histone acetylation and HDAC3.
Pasricha SR, Lim PJ, Duarte TL, Casu C, Oosterhuis D, Mleczko-Sanecka K, Suciu M, Da Silva AR, Al-Hourani K, Arezes J, McHugh K, Gooding S, Frost JN, Wray K, Santos A, Porto G, Repapi E, Gray N, Draper SJ, Ashley N, Soilleux E, Olinga P, Muckenthaler MU, Hughes JR, Rivella S, Milne TA, Armitage AE, Drakesmith H. Pasricha SR, et al. Among authors: santos a. Nat Commun. 2017 Sep 1;8(1):403. doi: 10.1038/s41467-017-00500-z. Nat Commun. 2017. PMID: 28864822 Free PMC article.
Nrf2 controls iron homeostasis in haemochromatosis and thalassaemia via Bmp6 and hepcidin.
Lim PJ, Duarte TL, Arezes J, Garcia-Santos D, Hamdi A, Pasricha SR, Armitage AE, Mehta H, Wideman S, Santos AG, Santos-Gonçalves A, Morovat A, Hughes JR, Soilleux E, Wang CY, Bayer AL, Klenerman P, Willberg CB, Hartley RC, Murphy MP, Babitt JL, Ponka P, Porto G, Drakesmith H. Lim PJ, et al. Among authors: santos goncalves a, santos ag. Nat Metab. 2019 May;1(5):519-531. doi: 10.1038/s42255-019-0063-6. Epub 2019 May 13. Nat Metab. 2019. PMID: 31276102 Free PMC article.
Iron overload induces dysplastic erythropoiesis and features of myelodysplasia in Nrf2-deficient mice.
Duarte TL, Lopes M, Oliveira M, Santos AG, Vasco C, Reis JP, Antunes AR, Gonçalves A, Chacim S, Oliveira C, Porto B, Teles MJ, Moreira AC, Silva AMN, Schwessinger R, Drakesmith H, Henrique R, Porto G, Duarte D. Duarte TL, et al. Among authors: santos ag. Leukemia. 2024 Jan;38(1):96-108. doi: 10.1038/s41375-023-02067-9. Epub 2023 Oct 19. Leukemia. 2024. PMID: 37857886
An essential cell-autonomous role for hepcidin in cardiac iron homeostasis.
Lakhal-Littleton S, Wolna M, Chung YJ, Christian HC, Heather LC, Brescia M, Ball V, Diaz R, Santos A, Biggs D, Clarke K, Davies B, Robbins PA. Lakhal-Littleton S, et al. Among authors: santos a. Elife. 2016 Nov 29;5:e19804. doi: 10.7554/eLife.19804. Elife. 2016. PMID: 27897970 Free PMC article.
Cardiac ferroportin regulates cellular iron homeostasis and is important for cardiac function.
Lakhal-Littleton S, Wolna M, Carr CA, Miller JJ, Christian HC, Ball V, Santos A, Diaz R, Biggs D, Stillion R, Holdship P, Larner F, Tyler DJ, Clarke K, Davies B, Robbins PA. Lakhal-Littleton S, et al. Among authors: santos a. Proc Natl Acad Sci U S A. 2015 Mar 10;112(10):3164-9. doi: 10.1073/pnas.1422373112. Epub 2015 Feb 23. Proc Natl Acad Sci U S A. 2015. PMID: 25713362 Free PMC article.
An integrated view of cisplatin-induced nephrotoxicity, hepatotoxicity, and cardiotoxicity: characteristics, common molecular mechanisms, and current clinical management.
Oliveira CA, Mercês ÉAB, Portela FS, Malheiro LFL, Silva HBL, De Benedictis LM, De Benedictis JM, Silva CCDE, Santos ACL, Rosa DP, Velozo HS, de Jesus Soares T, de Brito Amaral LS. Oliveira CA, et al. Among authors: santos acl. Clin Exp Nephrol. 2024 Apr 27. doi: 10.1007/s10157-024-02490-x. Online ahead of print. Clin Exp Nephrol. 2024. PMID: 38678166 Review.
In vitro Evaluation of Fungal Susceptibility and Inhibition of Virulence by Diosgenin.
Costa M, Silva AR, Araújo N, Santos A, Fonseca V, Alencar G, Moura T, Gonçalves S, Barbosa Filho J, Morais-Braga MF, Pinheiro J, Coutinho H. Costa M, et al. Among authors: santos a. Chem Biodivers. 2024 Apr 26:e202400444. doi: 10.1002/cbdv.202400444. Online ahead of print. Chem Biodivers. 2024. PMID: 38670923
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