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Inhibition of bacterial RNA polymerase by streptolydigin: stabilization of a straight-bridge-helix active-center conformation.
Tuske S, Sarafianos SG, Wang X, Hudson B, Sineva E, Mukhopadhyay J, Birktoft JJ, Leroy O, Ismail S, Clark AD Jr, Dharia C, Napoli A, Laptenko O, Lee J, Borukhov S, Ebright RH, Arnold E. Tuske S, et al. Among authors: sarafianos sg. Cell. 2005 Aug 26;122(4):541-52. doi: 10.1016/j.cell.2005.07.017. Cell. 2005. PMID: 16122422 Free PMC article.
The RNA polymerase "switch region" is a target for inhibitors.
Mukhopadhyay J, Das K, Ismail S, Koppstein D, Jang M, Hudson B, Sarafianos S, Tuske S, Patel J, Jansen R, Irschik H, Arnold E, Ebright RH. Mukhopadhyay J, et al. Cell. 2008 Oct 17;135(2):295-307. doi: 10.1016/j.cell.2008.09.033. Cell. 2008. PMID: 18957204 Free PMC article.
HIV-1 reverse transcriptase structure with RNase H inhibitor dihydroxy benzoyl naphthyl hydrazone bound at a novel site.
Himmel DM, Sarafianos SG, Dharmasena S, Hossain MM, McCoy-Simandle K, Ilina T, Clark AD Jr, Knight JL, Julias JG, Clark PK, Krogh-Jespersen K, Levy RM, Hughes SH, Parniak MA, Arnold E. Himmel DM, et al. Among authors: sarafianos sg. ACS Chem Biol. 2006 Dec 20;1(11):702-12. doi: 10.1021/cb600303y. ACS Chem Biol. 2006. PMID: 17184135 Free PMC article.
Structural basis for the role of the K65R mutation in HIV-1 reverse transcriptase polymerization, excision antagonism, and tenofovir resistance.
Das K, Bandwar RP, White KL, Feng JY, Sarafianos SG, Tuske S, Tu X, Clark AD Jr, Boyer PL, Hou X, Gaffney BL, Jones RA, Miller MD, Hughes SH, Arnold E. Das K, et al. Among authors: sarafianos sg. J Biol Chem. 2009 Dec 11;284(50):35092-100. doi: 10.1074/jbc.M109.022525. Epub 2009 Oct 7. J Biol Chem. 2009. PMID: 19812032 Free PMC article.
Structural basis of HIV-1 resistance to AZT by excision.
Tu X, Das K, Han Q, Bauman JD, Clark AD Jr, Hou X, Frenkel YV, Gaffney BL, Jones RA, Boyer PL, Hughes SH, Sarafianos SG, Arnold E. Tu X, et al. Among authors: sarafianos sg. Nat Struct Mol Biol. 2010 Oct;17(10):1202-9. doi: 10.1038/nsmb.1908. Epub 2010 Sep 19. Nat Struct Mol Biol. 2010. PMID: 20852643 Free PMC article.
204 results