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Absence of MMACHC in peripheral retinal cells does not lead to an ocular phenotype in mice.
Kiessling E, Nötzli S, Todorova V, Forny M, Baumgartner MR, Samardzija M, Krijt J, Kožich V, Grimm C, Froese DS. Kiessling E, et al. Among authors: notzli s. Biochim Biophys Acta Mol Basis Dis. 2021 Oct 1;1867(10):166201. doi: 10.1016/j.bbadis.2021.166201. Epub 2021 Jun 17. Biochim Biophys Acta Mol Basis Dis. 2021. PMID: 34147638 Free article.
The p66Shc knocked out mice are short lived under natural condition.
Giorgio M, Berry A, Berniakovich I, Poletaeva I, Trinei M, Stendardo M, Hagopian K, Ramsey JJ, Cortopassi G, Migliaccio E, Nötzli S, Amrein I, Lipp HP, Cirulli F, Pelicci PG. Giorgio M, et al. Among authors: notzli s. Aging Cell. 2012 Feb;11(1):162-8. doi: 10.1111/j.1474-9726.2011.00770.x. Epub 2011 Dec 28. Aging Cell. 2012. PMID: 22081964 Free article.