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Autoimmunity-associated T cell receptors recognize HLA-B*27-bound peptides.
Yang X, Garner LI, Zvyagin IV, Paley MA, Komech EA, Jude KM, Zhao X, Fernandes RA, Hassman LM, Paley GL, Savvides CS, Brackenridge S, Quastel MN, Chudakov DM, Bowness P, Yokoyama WM, McMichael AJ, Gillespie GM, Garcia KC. Yang X, et al. Among authors: savvides cs. Nature. 2022 Dec;612(7941):771-777. doi: 10.1038/s41586-022-05501-7. Epub 2022 Dec 7. Nature. 2022. PMID: 36477533 Free PMC article.
Immune receptor inhibition through enforced phosphatase recruitment.
Fernandes RA, Su L, Nishiga Y, Ren J, Bhuiyan AM, Cheng N, Kuo CJ, Picton LK, Ohtsuki S, Majzner RG, Rietberg SP, Mackall CL, Yin Q, Ali LR, Yang X, Savvides CS, Sage J, Dougan M, Garcia KC. Fernandes RA, et al. Among authors: savvides cs. Nature. 2020 Oct;586(7831):779-784. doi: 10.1038/s41586-020-2851-2. Epub 2020 Oct 21. Nature. 2020. PMID: 33087934 Free PMC article.
Facile repurposing of peptide-MHC-restricted antibodies for cancer immunotherapy.
Yang X, Nishimiya D, Löchte S, Jude KM, Borowska M, Savvides CS, Dougan M, Su L, Zhao X, Piehler J, Garcia KC. Yang X, et al. Among authors: savvides cs. Nat Biotechnol. 2023 Jul;41(7):932-943. doi: 10.1038/s41587-022-01567-w. Epub 2023 Jan 2. Nat Biotechnol. 2023. PMID: 36593402 Free PMC article.
Engineering a Single-Agent Cytokine/Antibody Fusion That Selectively Expands Regulatory T Cells for Autoimmune Disease Therapy.
Spangler JB, Trotta E, Tomala J, Peck A, Young TA, Savvides CS, Silveria S, Votavova P, Salafsky J, Pande VS, Kovar M, Bluestone JA, Garcia KC. Spangler JB, et al. Among authors: savvides cs. J Immunol. 2018 Oct 1;201(7):2094-2106. doi: 10.4049/jimmunol.1800578. Epub 2018 Aug 13. J Immunol. 2018. PMID: 30104245 Free PMC article.