Sawyers CL - Search Results

1

Allosteric interactions prime androgen receptor dimerization and activation.

Wasmuth EV, Broeck AV, LaClair JR, Hoover EA, Lawrence KE, Paknejad N, Pappas K, Matthies D, Wang B, Feng W, Watson PA, Zinder JC, Karthaus WR, de la Cruz MJ, Hite RK, Manova-Todorova K, Yu Z, Weintraub ST, Klinge S, Sawyers CL. Wasmuth EV, et al. Among authors: sawyers cl. Mol Cell. 2022 Jun 2;82(11):2021-2031.e5. doi: 10.1016/j.molcel.2022.03.035. Epub 2022 Apr 20. Mol Cell. 2022. PMID: 35447082 Free PMC article.

2

Biology of progressive, castration-resistant prostate cancer: directed therapies targeting the androgen-receptor signaling axis.

Scher HI, Sawyers CL. Scher HI, et al. Among authors: sawyers cl. J Clin Oncol. 2005 Nov 10;23(32):8253-61. doi: 10.1200/JCO.2005.03.4777. J Clin Oncol. 2005. PMID: 16278481 Review.

3

Context-dependent hormone-refractory progression revealed through characterization of a novel murine prostate cancer cell line.

Watson PA, Ellwood-Yen K, King JC, Wongvipat J, Lebeau MM, Sawyers CL. Watson PA, et al. Among authors: sawyers cl. Cancer Res. 2005 Dec 15;65(24):11565-71. doi: 10.1158/0008-5472.CAN-05-3441. Cancer Res. 2005. PMID: 16357166

4

Murine cell lines derived from Pten null prostate cancer show the critical role of PTEN in hormone refractory prostate cancer development.

Jiao J, Wang S, Qiao R, Vivanco I, Watson PA, Sawyers CL, Wu H. Jiao J, et al. Among authors: sawyers cl. Cancer Res. 2007 Jul 1;67(13):6083-91. doi: 10.1158/0008-5472.CAN-06-4202. Cancer Res. 2007. PMID: 17616663

5

Targeting the androgen receptor pathway in prostate cancer.

Chen Y, Sawyers CL, Scher HI. Chen Y, et al. Among authors: sawyers cl. Curr Opin Pharmacol. 2008 Aug;8(4):440-8. doi: 10.1016/j.coph.2008.07.005. Epub 2008 Aug 12. Curr Opin Pharmacol. 2008. PMID: 18674639 Free PMC article. Review.

6

Development of a second-generation antiandrogen for treatment of advanced prostate cancer.

Tran C, Ouk S, Clegg NJ, Chen Y, Watson PA, Arora V, Wongvipat J, Smith-Jones PM, Yoo D, Kwon A, Wasielewska T, Welsbie D, Chen CD, Higano CS, Beer TM, Hung DT, Scher HI, Jung ME, Sawyers CL. Tran C, et al. Among authors: sawyers cl. Science. 2009 May 8;324(5928):787-90. doi: 10.1126/science.1168175. Epub 2009 Apr 9. Science. 2009. PMID: 19359544 Free PMC article. Clinical Trial.

7

Constitutively active androgen receptor splice variants expressed in castration-resistant prostate cancer require full-length androgen receptor.

Watson PA, Chen YF, Balbas MD, Wongvipat J, Socci ND, Viale A, Kim K, Sawyers CL. Watson PA, et al. Among authors: sawyers cl. Proc Natl Acad Sci U S A. 2010 Sep 28;107(39):16759-65. doi: 10.1073/pnas.1012443107. Epub 2010 Sep 7. Proc Natl Acad Sci U S A. 2010. PMID: 20823238 Free PMC article.

8

Reciprocal feedback regulation of PI3K and androgen receptor signaling in PTEN-deficient prostate cancer.

Carver BS, Chapinski C, Wongvipat J, Hieronymus H, Chen Y, Chandarlapaty S, Arora VK, Le C, Koutcher J, Scher H, Scardino PT, Rosen N, Sawyers CL. Carver BS, et al. Among authors: sawyers cl. Cancer Cell. 2011 May 17;19(5):575-86. doi: 10.1016/j.ccr.2011.04.008. Cancer Cell. 2011. PMID: 21575859 Free PMC article.

9

Imaging androgen receptor signaling with a radiotracer targeting free prostate-specific antigen.

Ulmert D, Evans MJ, Holland JP, Rice SL, Wongvipat J, Pettersson K, Abrahamsson PA, Scardino PT, Larson SM, Lilja H, Lewis JS, Sawyers CL. Ulmert D, et al. Among authors: sawyers cl. Cancer Discov. 2012 Apr;2(4):320-7. doi: 10.1158/2159-8290.CD-11-0316. Epub 2012 Mar 31. Cancer Discov. 2012. PMID: 22576209 Free PMC article.

10

Overcoming mutation-based resistance to antiandrogens with rational drug design.

Balbas MD, Evans MJ, Hosfield DJ, Wongvipat J, Arora VK, Watson PA, Chen Y, Greene GL, Shen Y, Sawyers CL. Balbas MD, et al. Among authors: sawyers cl. Elife. 2013 Apr 9;2:e00499. doi: 10.7554/eLife.00499. Elife. 2013. PMID: 23580326 Free PMC article.

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