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Polθ inhibitors elicit BRCA-gene synthetic lethality and target PARP inhibitor resistance.
Zatreanu D, Robinson HMR, Alkhatib O, Boursier M, Finch H, Geo L, Grande D, Grinkevich V, Heald RA, Langdon S, Majithiya J, McWhirter C, Martin NMB, Moore S, Neves J, Rajendra E, Ranzani M, Schaedler T, Stockley M, Wiggins K, Brough R, Sridhar S, Gulati A, Shao N, Badder LM, Novo D, Knight EG, Marlow R, Haider S, Callen E, Hewitt G, Schimmel J, Prevo R, Alli C, Ferdinand A, Bell C, Blencowe P, Bot C, Calder M, Charles M, Curry J, Ekwuru T, Ewings K, Krajewski W, MacDonald E, McCarron H, Pang L, Pedder C, Rigoreau L, Swarbrick M, Wheatley E, Willis S, Wong AC, Nussenzweig A, Tijsterman M, Tutt A, Boulton SJ, Higgins GS, Pettitt SJ, Smith GCM, Lord CJ. Zatreanu D, et al. Among authors: schaedler t. Nat Commun. 2021 Jun 17;12(1):3636. doi: 10.1038/s41467-021-23463-8. Nat Commun. 2021. PMID: 34140467 Free PMC article.
Discovery, Characterization, and Structure-Based Optimization of Small-Molecule In Vitro and In Vivo Probes for Human DNA Polymerase Theta.
Stockley ML, Ferdinand A, Benedetti G, Blencowe P, Boyd SM, Calder M, Charles MD, Edwardes LV, Ekwuru T, Finch H, Galbiati A, Geo L, Grande D, Grinkevich V, Holliday ND, Krajewski WW, MacDonald E, Majithiya JB, McCarron H, McWhirter CL, Patel V, Pedder C, Rajendra E, Ranzani M, Rigoreau LJM, Robinson HMR, Schaedler T, Sirina J, Smith GCM, Swarbrick ME, Turnbull AP, Willis S, Heald RA. Stockley ML, et al. Among authors: schaedler t. J Med Chem. 2022 Oct 27;65(20):13879-13891. doi: 10.1021/acs.jmedchem.2c01142. Epub 2022 Oct 6. J Med Chem. 2022. PMID: 36200480
Structures and functions of mitochondrial ABC transporters.
Schaedler TA, Faust B, Shintre CA, Carpenter EP, Srinivasan V, van Veen HW, Balk J. Schaedler TA, et al. Biochem Soc Trans. 2015 Oct;43(5):943-51. doi: 10.1042/BST20150118. Biochem Soc Trans. 2015. PMID: 26517908 Review.
Peroxisomal ABC transporters: functions and mechanism.
Baker A, Carrier DJ, Schaedler T, Waterham HR, van Roermund CW, Theodoulou FL. Baker A, et al. Among authors: schaedler t. Biochem Soc Trans. 2015 Oct;43(5):959-65. doi: 10.1042/BST20150127. Epub 2015 Oct 9. Biochem Soc Trans. 2015. PMID: 26517910 Free PMC article. Review.
Iron cofactor assembly in plants.
Balk J, Schaedler TA. Balk J, et al. Annu Rev Plant Biol. 2014;65:125-53. doi: 10.1146/annurev-arplant-050213-035759. Epub 2014 Jan 29. Annu Rev Plant Biol. 2014. PMID: 24498975 Review.
21 results