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Modulating Hinge Flexibility in the APP Transmembrane Domain Alters γ-Secretase Cleavage.
Götz A, Mylonas N, Högel P, Silber M, Heinel H, Menig S, Vogel A, Feyrer H, Huster D, Luy B, Langosch D, Scharnagl C, Muhle-Goll C, Kamp F, Steiner H. Götz A, et al. Among authors: scharnagl c. Biophys J. 2019 Jun 4;116(11):2103-2120. doi: 10.1016/j.bpj.2019.04.030. Epub 2019 May 3. Biophys J. 2019. PMID: 31130234 Free PMC article.
The backbone dynamics of the amyloid precursor protein transmembrane helix provides a rationale for the sequential cleavage mechanism of γ-secretase.
Pester O, Barrett PJ, Hornburg D, Hornburg P, Pröbstle R, Widmaier S, Kutzner C, Dürrbaum M, Kapurniotu A, Sanders CR, Scharnagl C, Langosch D. Pester O, et al. Among authors: scharnagl c. J Am Chem Soc. 2013 Jan 30;135(4):1317-29. doi: 10.1021/ja3112093. Epub 2013 Jan 16. J Am Chem Soc. 2013. PMID: 23265086 Free PMC article.
The dynamics of γ-secretase and its substrates.
Hitzenberger M, Götz A, Menig S, Brunschweiger B, Zacharias M, Scharnagl C. Hitzenberger M, et al. Among authors: scharnagl c. Semin Cell Dev Biol. 2020 Sep;105:86-101. doi: 10.1016/j.semcdb.2020.04.008. Epub 2020 May 16. Semin Cell Dev Biol. 2020. PMID: 32423851 Review.
18 results