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De novo lipogenesis is essential for platelet production in humans.
Nat Metab. 2020 Oct;2(10):1163-1178. doi: 10.1038/s42255-020-00272-9. Epub 2020 Sep 14.
Nat Metab. 2020.
PMID: 32929234
Clinical Trial.
Small structural changes of the imidazopyridine diacylglycerol acyltransferase 2 (DGAT2) inhibitors produce an improved safety profile.
Futatsugi K, Huard K, Kung DW, Pettersen JC, Flynn DA, Gosset JR, Aspnes GE, Barnes RJ, Cabral S, Dowling MS, Fernando DP, Goosen TC, Gorczyca WP, Hepworth D, Herr M, Lavergne S, Li Q, Niosi M, Orr STM, Pardo ID, Perez SM, Purkal J, Schmahai TJ, Shirai N, Shoieb AM, Zhou J, Goodwin B.
Futatsugi K, et al. Among authors: schmahai tj.
Medchemcomm. 2016 Nov 22;8(4):771-779. doi: 10.1039/c6md00564k. eCollection 2017 Apr 1.
Medchemcomm. 2016.
PMID: 30108796
Free PMC article.
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Discovery of microsomal triglyceride transfer protein (MTP) inhibitors with potential for decreased active metabolite load compared to dirlotapide.
Robinson RP, Bartlett JA, Bertinato P, Bessire AJ, Cosgrove J, Foley PM, Manion TB, Minich ML, Ramos B, Reese MR, Schmahai TJ, Swick AG, Tess DA, Vaz A, Wolford A.
Robinson RP, et al. Among authors: schmahai tj.
Bioorg Med Chem Lett. 2011 Jul 15;21(14):4150-4. doi: 10.1016/j.bmcl.2011.05.099. Epub 2011 Jun 2.
Bioorg Med Chem Lett. 2011.
PMID: 21684740
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The safety of dirlotapide in dogs.
Wren JA, King VL, Krautmann MJ, Gossellin J, Kerlin RL, Hickman MA, Schmahai TJ.
Wren JA, et al. Among authors: schmahai tj.
J Vet Pharmacol Ther. 2007 Aug;30 Suppl 1:43-54. doi: 10.1111/j.1365-2885.2007.00854.x.
J Vet Pharmacol Ther. 2007.
PMID: 17567514
Clinical Trial.
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Administration of an antagonist of neurokinin receptors 1, 2, and 3 results in reproductive tract changes in beagle dogs, but not rats.
Losco PE, Leach MW, Sinha D, Davis P, Schmahai TJ, Nomier A, Kakkar T, Reyderman L, Lynch ME.
Losco PE, et al. Among authors: schmahai tj.
Toxicol Pathol. 2007 Feb;35(2):310-22. doi: 10.1080/01926230701198766.
Toxicol Pathol. 2007.
PMID: 17366326
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Preclinical safety evaluation of recombinant human interleukin-10.
Rosenblum IY, Johnson RC, Schmahai TJ.
Rosenblum IY, et al. Among authors: schmahai tj.
Regul Toxicol Pharmacol. 2002 Feb;35(1):56-71. doi: 10.1006/rtph.2001.1504.
Regul Toxicol Pharmacol. 2002.
PMID: 11846636
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Correlation between thiopental induction dose and the volume of distribution of caffeine in human subjects.
DeLaRocha A, Inchiosa MA Jr, Milliken RA, Schmahai TJ, Bizzarri DV.
DeLaRocha A, et al. Among authors: schmahai tj.
J Clin Pharmacol. 1986 Mar;26(3):191-4. doi: 10.1002/j.1552-4604.1986.tb02932.x.
J Clin Pharmacol. 1986.
PMID: 3958224
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Prediction of thiopental induction dose based on caffeine volume of distribution.
Inchiosa MA Jr, Schmahai TJ, Phang W, Inchiosa ME, Bizzarri DV.
Inchiosa MA Jr, et al. Among authors: schmahai tj.
J Clin Pharmacol. 1985 May-Jun;25(4):281-4. doi: 10.1002/j.1552-4604.1985.tb02839.x.
J Clin Pharmacol. 1985.
PMID: 4008673
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