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The Rho-deamidating cytotoxic necrotizing factor 1 from Escherichia coli possesses transglutaminase activity. Cysteine 866 and histidine 881 are essential for enzyme activity.
Schmidt G, Selzer J, Lerm M, Aktories K. Schmidt G, et al. J Biol Chem. 1998 May 29;273(22):13669-74. doi: 10.1074/jbc.273.22.13669. J Biol Chem. 1998. PMID: 9593707 Free article.
Recently, it has been reported that cytotoxic necrotizing factor 1 (CNF1) from Escherichia coli induces formation of stress fibers by deamidation of glutamine 63 of RhoA (Schmidt, G., Sehr, P., Wilm, M., Selzer, J., Mann, M., and Aktories, K. (1997) Nature 387, 725- …
Recently, it has been reported that cytotoxic necrotizing factor 1 (CNF1) from Escherichia coli induces formation of stress fibers by deamid …
Bacterial cytotoxins target Rho GTPases.
Schmidt G, Aktories K. Schmidt G, et al. Naturwissenschaften. 1998 Jun;85(6):253-61. doi: 10.1007/s001140050495. Naturwissenschaften. 1998. PMID: 9686394 Review.
Deamidation of Cdc42 and Rac by Escherichia coli cytotoxic necrotizing factor 1: activation of c-Jun N-terminal kinase in HeLa cells.
Lerm M, Selzer J, Hoffmeyer A, Rapp UR, Aktories K, Schmidt G. Lerm M, et al. Among authors: schmidt g. Infect Immun. 1999 Feb;67(2):496-503. doi: 10.1128/IAI.67.2.496-503.1999. Infect Immun. 1999. PMID: 9916051 Free PMC article.
Recently, Escherichia coli cytotoxic necrotizing factor 1 (CNF1) was shown to activate the low-molecular-mass GTPase RhoA by deamidation of Gln63, thereby inhibiting intrinsic and GTPase-activating protein (GAP)-stimulated GTPase activities (G. Schmidt, P. Sehr, M. …
Recently, Escherichia coli cytotoxic necrotizing factor 1 (CNF1) was shown to activate the low-molecular-mass GTPase RhoA by deamidation of …
2,623 results