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Page 1
Identifying new lead structures to enhance tolerance towards drought stress via high-throughput screening giving crops a quantum of solace.
Frackenpohl J, Schneider L, Decker LJB, Dittgen J, Fenkl F, Fischer C, Franke J, Freigang J, Getachew R, Gonzalez Fernandez-Nino SM, Helmke H, Hills MJ, Hohmann S, Kleemann J, Kurowski K, Lange G, Luemmen P, Meyering N, Poree F, Schmutzler D, Wrede S. Frackenpohl J, et al. Among authors: schmutzler d. Bioorg Med Chem. 2019 Dec 15;27(24):115142. doi: 10.1016/j.bmc.2019.115142. Epub 2019 Oct 19. Bioorg Med Chem. 2019. PMID: 31685332
Tetrahydroquinolinyl phosphinamidates and phosphonamidates enhancing tolerance towards drought stress in crops via interaction with ABA receptor proteins.
Frackenpohl J, Decker LJB, Dittgen J, Freigang J, Génix P, Helmke H, Lange G, Luemmen P, Schmidt J, Schmutzler D, Vors JP. Frackenpohl J, et al. Among authors: schmutzler d. Bioorg Med Chem. 2020 Nov 15;28(22):115725. doi: 10.1016/j.bmc.2020.115725. Epub 2020 Aug 30. Bioorg Med Chem. 2020. PMID: 33007548
A Study in Scaffold Hopping: Discovery and Optimization of Thiazolopyridines as Potent Herbicides That Inhibit Acyl-ACP Thioesterase.
Abel SAG, Alnafta N, Asmus E, Bollenbach-Wahl B, Braun R, Dittgen J, Endler A, Frackenpohl J, Freigang J, Gatzweiler E, Heinemann I, Helmke H, Laber B, Lange G, Machettira A, McArthur G, Müller T, Odaybat M, Reingruber AM, Roth S, Rosinger CH, Schmutzler D, Schulte W, Stoppel R, Tiebes J, Volpin G, Barber DM. Abel SAG, et al. Among authors: schmutzler d. J Agric Food Chem. 2023 Nov 29;71(47):18212-18226. doi: 10.1021/acs.jafc.3c02490. Epub 2023 Sep 7. J Agric Food Chem. 2023. PMID: 37677080
Investigations into Simplified Analogues of the Herbicidal Natural Product (+)-Cornexistin.
Steinborn C, Tancredi A, Habiger C, Diederich C, Kramer J, Reingruber AM, Laber B, Freigang J, Lange G, Schmutzler D, Machettira A, Besong G, Magauer T, Barber DM. Steinborn C, et al. Among authors: schmutzler d. Chemistry. 2023 Jul 11;29(39):e202300199. doi: 10.1002/chem.202300199. Epub 2023 May 23. Chemistry. 2023. PMID: 36807428 Free PMC article.
Synthesis and biological profile of 2,3-dihydro[1,3]thiazolo[4,5-b]pyridines, a novel class of acyl-ACP thioesterase inhibitors.
Frackenpohl J, Barber DM, Bojack G, Bollenbach-Wahl B, Braun R, Getachew R, Hohmann S, Ko KY, Kurowski K, Laber B, Mattison RL, Müller T, Reingruber AM, Schmutzler D, Svejda A. Frackenpohl J, et al. Among authors: schmutzler d. Beilstein J Org Chem. 2024 Mar 1;20:540-551. doi: 10.3762/bjoc.20.46. eCollection 2024. Beilstein J Org Chem. 2024. PMID: 38440172 Free PMC article.
Discovery and optimization of spirocyclic lactams that inhibit acyl-ACP thioesterase.
Asmus E, Barber DM, Bojack G, Bollenbach-Wahl B, Brown RW, Döller U, Freigang J, Gatzweiler E, Getachew R, Heinemann I, Hohmann S, Ko KY, Laber B, Lange G, Mattison RL, Minn K, Müller T, Petry T, Reingruber AM, Schmutzler D, Svejda A, Frackenpohl J. Asmus E, et al. Among authors: schmutzler d. Pest Manag Sci. 2024 Feb 9. doi: 10.1002/ps.8015. Online ahead of print. Pest Manag Sci. 2024. PMID: 38334233