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The USP7-TRIM27 axis mediates non-canonical PRC1.1 function and is a druggable target in leukemia.
Maat H, Atsma TJ, Hogeling SM, Rodríguez López A, Jaques J, Olthuis M, de Vries MP, Gravesteijn C, Brouwers-Vos AZ, van der Meer N, Datema S, Salzbrunn J, Huls G, Baas R, Martens JHA, van den Boom V, Schuringa JJ. Maat H, et al. Among authors: schuringa jj. iScience. 2021 Apr 16;24(5):102435. doi: 10.1016/j.isci.2021.102435. eCollection 2021 May 21. iScience. 2021. PMID: 34113809 Free PMC article.
BMI1 collaborates with BCR-ABL in leukemic transformation of human CD34+ cells.
Rizo A, Horton SJ, Olthof S, Dontje B, Ausema A, van Os R, van den Boom V, Vellenga E, de Haan G, Schuringa JJ. Rizo A, et al. Among authors: schuringa jj. Blood. 2010 Nov 25;116(22):4621-30. doi: 10.1182/blood-2010-02-270660. Epub 2010 Aug 19. Blood. 2010. PMID: 20724541 Free article.
Gene expression profiling in the leukemic stem cell-enriched CD34+ fraction identifies target genes that predict prognosis in normal karyotype AML.
de Jonge HJ, Woolthuis CM, Vos AZ, Mulder A, van den Berg E, Kluin PM, van der Weide K, de Bont ES, Huls G, Vellenga E, Schuringa JJ. de Jonge HJ, et al. Among authors: schuringa jj. Leukemia. 2011 Dec;25(12):1825-33. doi: 10.1038/leu.2011.172. Epub 2011 Jul 15. Leukemia. 2011. PMID: 21760593 Clinical Trial.
Nonredundant and locus-specific gene repression functions of PRC1 paralog family members in human hematopoietic stem/progenitor cells.
van den Boom V, Rozenveld-Geugien M, Bonardi F, Malanga D, van Gosliga D, Heijink AM, Viglietto G, Morrone G, Fusetti F, Vellenga E, Schuringa JJ. van den Boom V, et al. Among authors: schuringa jj. Blood. 2013 Mar 28;121(13):2452-61. doi: 10.1182/blood-2012-08-451666. Epub 2013 Jan 24. Blood. 2013. PMID: 23349393 Free article.
136 results