Seiler SM - Search Results

1

Structure-activity relationships associated with 3,4,5-triphenyl-1H-pyrazole-1-nonanoic acid, a nonprostanoid prostacyclin mimetic.

Meanwell NA, Rosenfeld MJ, Wright JJ, Brassard CL, Buchanan JO, Federici ME, Fleming JS, Seiler SM. Meanwell NA, et al. Among authors: seiler sm. J Med Chem. 1992 Jan 24;35(2):389-97. doi: 10.1021/jm00080a028. J Med Chem. 1992. PMID: 1370696

2

Imidazoquinoline derivatives: potent inhibitors of platelet cAMP phosphodiesterase which elevate cAMP levels and activate protein kinase in platelets.

Seiler S, Gillespie E, Arnold AJ, Brassard CL, Meanwell NA, Fleming JS. Seiler S, et al. Thromb Res. 1991 Apr;62(1-2):31-42. doi: 10.1016/0049-3848(91)90666-k. Thromb Res. 1991. PMID: 1649498

3

SQ-27986 inhibition of platelet aggregation is mediated through activation of platelet prostaglandin D2 receptors.

Seiler S, Brassard CL, Federici ME. Seiler S, et al. Prostaglandins. 1990 Aug;40(2):119-30. doi: 10.1016/0090-6980(90)90078-a. Prostaglandins. 1990. PMID: 2171039

4

Octimibate inhibition of platelet aggregation: stimulation of adenylate cyclase through prostacyclin receptor activation.

Seiler S, Brassard CL, Arnold AJ, Meanwell NA, Fleming JS, Keely SL Jr. Seiler S, et al. J Pharmacol Exp Ther. 1990 Dec;255(3):1021-6. J Pharmacol Exp Ther. 1990. PMID: 2175792

5

Antithrombotic activity of BMY-43351, a new imidazoquinoline with enhanced aqueous solubility.

Fleming JS, Buchanan JO, Seiler SM, Meanwell NA. Fleming JS, et al. Among authors: seiler sm. Thromb Res. 1991 Jul 1;63(1):145-55. doi: 10.1016/0049-3848(91)90277-4. Thromb Res. 1991. PMID: 1948816

6

Azetidin-2-one derivatives as inhibitors of thrombin.

Han WT, Trehan AK, Wright JJ, Federici ME, Seiler SM, Meanwell NA. Han WT, et al. Among authors: seiler sm. Bioorg Med Chem. 1995 Aug;3(8):1123-43. doi: 10.1016/0968-0896(95)00101-l. Bioorg Med Chem. 1995. PMID: 7582985

7

Active site-directed thrombin inhibitors--II. Studies related to arginine/guanidine bioisosteres.

St Laurent DR, Balasubramanian N, Han WT, Trehan A, Federici ME, Meanwell NA, Wright JJ, Seiler SM. St Laurent DR, et al. Among authors: seiler sm. Bioorg Med Chem. 1995 Aug;3(8):1145-56. doi: 10.1016/0968-0896(95)00103-n. Bioorg Med Chem. 1995. PMID: 7582986

8

2-[3-[2-(4,5-Diphenyl-2-oxazolyl) ethyl] phenoxy] acetic acid (BMY 42393): a new, structurally-novel prostacyclin partial agonist: 1). Inhibition of platelet aggregation and mechanism of action.

Seiler SM, Brassard CL, Federici ME, Buchanan JO, Zavoico GB, Fleming JS, Meanwell NA. Seiler SM, et al. Thromb Res. 1994 Apr 15;74(2):115-23. doi: 10.1016/0049-3848(94)90004-3. Thromb Res. 1994. PMID: 8029812

9

Inhibitors of blood platelet cAMP phosphodiesterase. 4. Structural variation of the side-chain terminus of water-soluble 1,3-dihydro-2H-imidazo[4,5-b]quinolin-2-one derivatives.

Meanwell NA, Hewawasam P, Thomas JA, Wright JJ, Russell JW, Gamberdella M, Goldenberg HJ, Seiler SM, Zavoico GB. Meanwell NA, et al. Among authors: seiler sm. J Med Chem. 1993 Oct 29;36(22):3251-64. doi: 10.1021/jm00074a005. J Med Chem. 1993. PMID: 8230115

10

Active site-directed synthetic thrombin inhibitors: synthesis, in vitro and in vivo activity profile of BMY 44621 and analogs. An examination of the role of the amino group in the D-Phe-Pro-Arg-H series.

Balasubramanian N, St Laurent DR, Federici ME, Meanwell NA, Wright JJ, Schumacher WA, Seiler SM. Balasubramanian N, et al. Among authors: seiler sm. J Med Chem. 1993 Jan 22;36(2):300-3. doi: 10.1021/jm00054a018. J Med Chem. 1993. PMID: 8423602 No abstract available.

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