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Diet and exercise reduce pre-existing NASH and fibrosis and have additional beneficial effects on the vasculature, adipose tissue and skeletal muscle via organ-crosstalk.
Metabolism. 2021 Nov;124:154873. doi: 10.1016/j.metabol.2021.154873. Epub 2021 Sep 1.
Metabolism. 2021.
PMID: 34478753
Free article.
A novel nutritional supplement prevents muscle loss and accelerates muscle mass recovery in caloric-restricted mice.
van den Hoek AM, Zondag GCM, Verschuren L, de Ruiter C, Attema J, de Wit EC, Schwerk AMK, Guigas B, Lek S, Rietman A, Strijker R, Kleemann R.
van den Hoek AM, et al. Among authors: lek s.
Metabolism. 2019 Aug;97:57-67. doi: 10.1016/j.metabol.2019.05.012. Epub 2019 May 31.
Metabolism. 2019.
PMID: 31153978
Free article.
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Translational characterization of the temporal dynamics of metabolic dysfunctions in liver, adipose tissue and the gut during diet-induced NASH development in Ldlr-/-.Leiden mice.
Gart E, van Duyvenvoorde W, Snabel JM, de Ruiter C, Attema J, Caspers MPM, Lek S, van Heuven BJ, Speksnijder AGCL, Giera M, Menke A, Salic K, Bence KK, Tesz GJ, Keijer J, Kleemann R, Morrison MC.
Gart E, et al. Among authors: lek s.
Heliyon. 2023 Feb 24;9(3):e13985. doi: 10.1016/j.heliyon.2023.e13985. eCollection 2023 Mar.
Heliyon. 2023.
PMID: 36915476
Free PMC article.
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Caloric Restriction Combined with Immobilization as Translational Model for Sarcopenia Expressing Key-Pathways of Human Pathology.
de Jong JCBC, Caspers MPM, Keijzer N, Worms N, Attema J, de Ruiter C, Lek S, Nieuwenhuizen AG, Keijer J, Menke AL, Kleemann R, Verschuren L, van den Hoek AM.
de Jong JCBC, et al. Among authors: lek s.
Aging Dis. 2023 Jun 1;14(3):937-957. doi: 10.14336/AD.2022.1201.
Aging Dis. 2023.
PMID: 37191430
Free PMC article.
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