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Vitamin C activates pyruvate dehydrogenase (PDH) targeting the mitochondrial tricarboxylic acid (TCA) cycle in hypoxic KRAS mutant colon cancer.
Cenigaonandia-Campillo A, Serna-Blasco R, Gómez-Ocabo L, Solanes-Casado S, Baños-Herraiz N, Puerto-Nevado LD, Cañas JA, Aceñero MJ, García-Foncillas J, Aguilera Ó. Cenigaonandia-Campillo A, et al. Theranostics. 2021 Jan 25;11(8):3595-3606. doi: 10.7150/thno.51265. eCollection 2021. Theranostics. 2021. PMID: 33664850 Free PMC article.
KRAS p.G12C mutation occurs in 1% of EGFR-mutated advanced non-small-cell lung cancer patients progressing on a first-line treatment with a tyrosine kinase inhibitor.
Serna-Blasco R, Sánchez-Herrero E, Sanz-Moreno S, Rodriguez-Festa A, García-Veros E, Casarrubios M, Sierra-Rodero B, Laza-Briviesca R, Cruz-Bermúdez A, Mielgo-Rubio X, Sánchez-Hernández A, Uribelarrea EA, Calvo V, Romero A, Provencio M. Serna-Blasco R, et al. ESMO Open. 2021 Oct;6(5):100279. doi: 10.1016/j.esmoop.2021.100279. Epub 2021 Oct 1. ESMO Open. 2021. PMID: 34607284 Free PMC article.
NGS-based liquid biopsy profiling identifies mechanisms of resistance to ALK inhibitors: a step toward personalized NSCLC treatment.
Sánchez-Herrero E, Serna-Blasco R, Ivanchuk V, García-Campelo R, Dómine Gómez M, Sánchez JM, Massutí B, Reguart N, Camps C, Sanz-Moreno S, Calabuig-Fariñas S, Jantus-Lewintre E, Arnal M, Fernández-Orth D, Calvo V, González-Rumayor V, Provencio M, Romero A. Sánchez-Herrero E, et al. Mol Oncol. 2021 Sep;15(9):2363-2376. doi: 10.1002/1878-0261.13033. Epub 2021 Jun 18. Mol Oncol. 2021. PMID: 34058070 Free PMC article.
Sex is a strong prognostic factor in stage IV non-small-cell lung cancer patients and should be considered in survival rate estimation.
Barquín M, Calvo V, García-García F, Nuñez B, Sánchez-Herrero E, Serna-Blasco R, Auglytė M, Carcereny E, Rodriguez-Abreu D, López Castro R, Guirado M, Camps C, Bosch-Barrera J, Massuti B, Ortega AL, Del Barco E, Gonzalez-Larriba JL, Aguiar D, García-Campelo R, Dómine M, Agraso S, Sala MA, Oramas J, Bernabé R, Blanco R, Parejo C, Cruz A, Menasalvas E, Royuela A, Romero A, Provencio M. Barquín M, et al. Cancer Epidemiol. 2020 Aug;67:101737. doi: 10.1016/j.canep.2020.101737. Epub 2020 May 22. Cancer Epidemiol. 2020. PMID: 32450544
Analysis of circulating tumour DNA to identify patients with epidermal growth factor receptor-positive non-small cell lung cancer who might benefit from sequential tyrosine kinase inhibitor treatment.
Provencio M, Serna-Blasco R, Franco F, Calvo V, Royuela A, Auglytė M, Sánchez-Hernández A, de Julián Campayo M, García-Girón C, Dómine M, Blasco A, Sánchez JM, Oramas J, Bosch-Barrera J, Sala MÁ, Sereno M, Ortega AL, Chara L, Hernández B, Padilla A, Coves J, Blanco R, Balsalobre J, Mielgo X, Bueno C, Jantus-Lewintre E, Molina-Vila MÁ, Romero A. Provencio M, et al. Eur J Cancer. 2021 May;149:61-72. doi: 10.1016/j.ejca.2021.02.031. Epub 2021 Apr 5. Eur J Cancer. 2021. PMID: 33831609 Free article.
ALK-Fusion Transcripts Can Be Detected in Extracellular Vesicles (EVs) from Nonsmall Cell Lung Cancer Cell Lines and Patient Plasma: Toward EV-Based Noninvasive Testing.
Sánchez-Herrero E, Campos-Silva C, Cáceres-Martell Y, Robado de Lope L, Sanz-Moreno S, Serna-Blasco R, Rodríguez-Festa A, Ares Trotta D, Martín-Acosta P, Patiño C, Coronado MJ, Beneitez A, Jara R, Lago-Baameiro N, Camino T, Cruz-Bermúdez A, Pardo M, González-Rumayor V, Valés-Gómez M, Provencio M, Romero A. Sánchez-Herrero E, et al. Among authors: serna blasco r. Clin Chem. 2022 May 18;68(5):668-679. doi: 10.1093/clinchem/hvac021. Clin Chem. 2022. PMID: 35348673
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